Abstract:

Treatment of lower limb ischemia in Behcet disease and Takayasu’s arteritis        CHEN Yue-xin, ZHOU Xiang, LIU Chang-wei. Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Corresponding author: LIU Chang-wei, E-mail：liucw@vip.sina.com
Abstract    Although peripheral arterial atherosclerosis is known to be a major etiologic factor for lower limb ischemia, if it occurs in young patients in the absence of traditional risk factors for atherosclerosis, other non-atherosclerotic conditions must be considered, such as vasculitides, fibromuscular dysplasia, lower limb artery embolism or aortic dissection. Vasculitides refer to a heterogenous group of disorders that are characterized by inflammation within blood vessels and thus result in organ perfusion dysfunction and tissue necrosis. Vasculitides can involve multiple systems, its clinical manifestation can take on various looks, and diagnosis and treatment can usually be rather difficult. Lower limb ischemia could be part of clinical picture in giant-cell arteritis, Takayasu’s arteritis, Buerger's disease, polyarteritis nodosa or Behcet disease. Surgeons should pay attention to the treatment of Behçet disease and Takayasu’s arteritis, so as to improve the awareness of vasculitides as a rare cause of lower limb ischemia.

Key words: behcet disease, takayasu’s arteritis, lower limb ischemia

摘要：

动脉粥样硬化是下肢缺血最常见原因，但对于缺少心脑血管疾病危险因素的年轻病人，尚应考虑其他少见病因，如血管炎、纤维肌性发育不良、下肢动脉栓塞、主动脉夹层等。系统性血管炎以血管壁炎性反应为主要病理改变，从而导致相应组织器官的供血障碍和组织坏死。血管炎可累及全身各个系统，临床症状复杂，诊断与治疗棘手。下肢缺血可并发于巨细胞动脉炎、大动脉炎、Buerger病、结节性多动脉炎和白塞病等。对于少见病因如白塞病及大动脉炎并发的下肢缺血，值得引起临床医生的重视。

关键词: 白塞病, 大动脉炎, 下肢缺血