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15 March 2014, Volume 7 Issue 3 Previous Issue    Next Issue

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The application of digital surgical guide in clinical implant. ZHANG Jian， WANG Qing-fu， WANG Yan-ying， YANG Bi-jie 2014, 7(3): 129-133.  Abstract ( )   PDF (2339KB) ( )   Abstract：Today， restoration of dental implants is an effective method for the rehabilitation of partially and completely edentulous jaws. Meanwhile， the technique for computer guided implant placement has developed mostly due to achievements in radiographic three-dimensional （3D） imaging and rapid prototyping technique. This article will discuss the design protocol and accuracy of digital surgical guide， the application of digital surgical guide in different types of patients， and prospect of domestic digital surgical guide.

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Etiology and treatment of biological complications in implant denture. JIANG Lu-lu， ZHAO Bao-hong 2014, 7(3): 133-138.  Abstract ( )   PDF (1492KB) ( )   Abstract： Implant denture is a dental restoration treatment with a high success rate in patients with dentition defect or missing. However， any treatment is likely to be associated with complications. Complications generally were divided into two categories， biological complications and mechanical complications. Biological complications included： surgical bleeding， nerve injury， perforated of maxillary sinus， damage of adjacent tooth and postoperative infection， inflammation and loose of implants， etc. Mechanical complications included broken of screws， abutment and implant， restoration damage， etc. In this paper， with the purpose of providing reference for clinical doctors， we analyze etiology of biological complications， put forward the prevention and treatment by way of consulting lots of literature and integrating clinical experience.

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Preservation and restoration of residual root and crown. ZHU Zhi-min， XIAO Wei-xiong 2014, 7(3): 139-141.  Abstract ( )   PDF (1415KB) ( )   Abstract： The residual root and crown is remaining tooth structure after serious damaged. It is very important to restore this kind of tooth after root canal treatment. The protheses for preservation may contribute to the simplified treatment process， reduce the injury， improve the effect of restoration， reduce the alveolar bone resorption， and so on. The aim of this paper is discusses the preserving treatment indications of serious damaged tooth， and hope the principle of minimum injury and maximum preservation will be pay more attention to in clinic work.

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Effects of gossypol acetic acid on mRNA expressions of E-cadherin gene in human adenoid cystic carcinoma ACC-M cell and its significance. YUE Wan-yuan， CHEN Wen-fei， FU Shuai， WU Yong 2014, 7(3): 142-145.  Abstract ( )   PDF (865KB) ( )   Abstract： Objective To study the effects of gossypol acetic acid （GAA） on proliferation and the mRNA expressions of E-cadherin in human adenoid cystic carcinoma ACC-M Cell in vitro. Methods （1）MTT assay was used to detect the effects on proliferation in ACC-M cells treated by different concentration of GAA. （2）Real-time fluorescence quantitative PCR（RFQ-PCR）was used to detect mRNA expression level changes of the E-cadherin gene in ACC-M cells treated by GAA for 48h and 72h. Results （1） Experimental GAA group could be observed on growth and proliferation inhibition of E-cadherin cells after being treated by GAA. （2）Compared with the control group， the result of RFQ-PCR showed that mRNA expression of E-cadherin gene in ACC-M cells was increased after GAA treatment （19 μmol/L GAA for 48 h and 10 μmol/L for 72 h）（P < 0.05）. Conclusion GAA can suppress proliferation of ACC-M cells and also increase E-cadherin gene mRNA expression.

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Comparison of miRNAs expression profiles between human dental pulp stem cells and non-stem cells. LV Hong-bing*，ZHENG Bi-qiong，LEI Li-shan，ZHANG Ming，FU Sheng， FAN Li-na 2014, 7(3): 146-150.  Abstract ( )   PDF (1236KB) ( )   Abstract： Objective To observe the expression of miRNAs between human dental pulp stem cells （DPSCs） and human dental pulp non-stem cells and to analyze the roles of miRNA in the stemness of DPSCs. Methods DPSCs were isolated by immune-magnetic beads binding specific STRO-1 antibody separation system. Mineralization medium-induced odontoblasts-like cells differentiated from DPSCs were tested by ALP， OC values and von Kossa staining. Differential miRNAs of human dental pulp stem cells and non-stem cells were screened by microRNA array. Results miRNA microarrays revealed that 11 miRNAs were upregulated in DPSCs while 3 miRNAs were downregulated compared with non-stem cells. Conclusion Stemness of DPSCs may have a close relationship with differential miRNAs expression.

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Analysis of lip-nasal normal data of infants of Han nationality in Jiangxi province. ZHU Zhi-nong*，WANG Yu-jiang，ZHANG Qiang，PENG Tao，DING Shan 2014, 7(3): 151-154.  Abstract ( )   PDF (1101KB) ( )   Abstract：Objective To study the characteristics of the lip-nasal soft tissue profiles of Han infants in Jiangxi province，in order to provide reference for research and treatment of cleft lip. Methods One hundred and five Han infants（aged from 3 to 12 months ）in Jiangxi province were selected randomly，and divided into two groups：3 to 6 months group（29 males and 20 females）and 7 to 12 months group（38 males and 18 females）. The lip-nasal normal data，based on facial basic measurement indexes of anthropometry，were measured with a direct measurement method of a systematic maxillofacial anthropometry by Farkas. The data were analyzed by SPSS17.0 software package. Results The mean value and standard deviation of normal lip-nasal data of Han infants aged from 3 to 12 months in Jiangxi province were obtained. The nasorostral height，cupid's bow inner crista length，philtrum width and nostril base width of males were bigger than those of females in Han infants aged from 3 to 6 months（all P < 0.05）；the upper lip height，cupid's bow inner crista length，philtrum width and nostril base width of males were bigger than those of females in Han infants aged from 7 to 12 months（all P < 0.05）. Conclusion Gender differences are demonstrated in lip-nasal soft tissue profiles of Han infants in Jiangxi province and change regularly with the years and weight，which provides references for individulized treatments for cleft lip.

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The sealing effects and abrasive resistance of two desensitizers for dental tubules： an SEM investigation. HUANG Yan-hua， XIE Si-jing， GE Jiu-yu 2014, 7(3): 154-158.  Abstract ( )   PDF (1376KB) ( )   Abstract：Objective To evaluate the the sealing effects and abrasive resistance of ClinproTM XT Varnish and Oravive through scanning electron microscope （SEM）. Methods Totally 48 freshly extracted human premolars were selected， prepared into dentin discs， and randomly divided into 3 groups （group A： control group， group B： ClinproTM XT Varnish group，group C： Oravive group）. ClinproTM XT Varnish and Oravive were applied respectively on the exposed dentin surfaces of the B and C group in accordance with operating manual. Eight teeth of the B and C group were respectively selected for toothbrush abrasion test. Then an observation was made on the surface and the section plane by scanning election microscope and quantitative analysis was made with Image-Pro Plus 6.0. Results Both of the two desensitizers could occlude the dentinal surface， and dentinal tubule area and the relative area of the two groups had no significant difference （P > 0.05）. The two desensitizers could penetrate into the dentinal tubules at a certain depth， but the penetration depth in group B was larger than that in group C （P < 0.05）； after the toothbrush abrasion test， the sealing effect in group B was markedly superior to that in group C （P < 0.05）. Conclusion ClinproTM XT Varnish performs better than Oravive in sealing effect and abrasion resistance.

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Risk factors for vascular crisis in free flaps reconstruction of oral and maxillofacial defects. ZHANG Guo-run， SU Yu-xiong， LIANG Yu-jie， ZHENG Guang-sen， LIAO Gui-qing 2014, 7(3): 160-164.  Abstract ( )   PDF (1452KB) ( )   Abstract：Objective To investigate the risk factors for vascular crisis in free flaps reconstruction of oral and maxillofacial defects. Methods Clinical data of 451 free revascularized flaps in 451 patients performed in our department from December 2000 to October 2013 were reviewed. Statistical analysis was done using SPSS statistical software （SPSS for Windows Version17.0）. Univariate statistical analysis was performed to analyze the factors predicting vessel crisis using χ2 and 2-tailed t test methods. For those factors showing statistical significance on univariate analysis （P＜0.05），multivariate logistical regression analysis was then undertaken. Results Forty-three flaps developed vascular crisis （9.53%）， most of which were caused by venous crisis （33/43）. Forty flaps were explored with 22 flaps successfully salvaged， and the success rate was as high as 55%. Univariate analysis showed that end-to-side venous anastomosis and preoperative radiotherapy were of statistical significance （P＜0.05）， but multivariate logistic regression analysis showed that only end-to-side venous anastomosis was of statistical significance. Conclusion The surgical exploration should be done as soon as possible after vascular crisis occurs to get a higher success rate. End-to-side venous anastomosis may be a risk factor in free tissue transfer.

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Effect of diclofenac sodium on the expression of IL-1βand TNF-α in human periodontal ligament fibroblasts induced by lipopolysaccharide. KANG Qian， ZHAO Bin 2014, 7(3): 164-167.  Abstract ( )   PDF (869KB) ( )   Abstract： Objective To explore effects of different dosage of diclofenac sodium combined with lipopolysaccharide （LPS） on expression of IL-1βand TNF-αin human periodontal ligament fibroblasts（HPDLFs）. Methods Take cryopreserved HPDLFs to culture. After cell morphology identification and being induced by 10 μg/mL of LPS， the HPDLFs were intervened respectively by 0.1，1， 10， 50 and 100mg/L of diclofenac sodium. Then the changes of the expression levels of IL-1βand TNF-α in cultured HPDLFs were observed by ELISA method. Results Diclofenac sodium was able to down-regulate the expression level of IL-1βand TNF-α in cultured HPDLFs which was induced by the same concentration of LPS. And the gradually decreasing trend of IL-1β and TNF-α expression was obviously related to the increasing diclofenac sodium dosage （P＜0.05）. Conclusion Diclofenac sodium may play an important role in inhibiting the expression of IL-1βand TNF-α in LPS-induced HPDLFs， which provides a new way of the clinical treatment for periodontal diseases.

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Study on the masticatory efficiency and the occlusal force in different types of complete denture. MIAO Li-ya，AI Hong-jun 2014, 7(3): 168-171.  Abstract ( )   PDF (873KB) ( )   Abstract：Objective To compare the difference in the masticatory efficiency and the occlusal force in two different types of complete denture for edentulous patients with low alveolar ridge：the lingualized occlusion and the anatomic bilateral balanced occlusion. Methods Totally 20 patients with the residual resorption of the edentulous were collected from Department of Prosthodontics，School of Stomatology，China Medical University. Two different types of complete dentures （the lingualized occlusion and the anatomic bilateral balanced occlusion）were made for each patient in the same vertical distance and centric relation occlusion record using closed-type impression techniques. Each patient randomly received both the two types of complete dentures. Each pair of dentures was measured the masticatory efficiency by light absorption method and the maximal bite force was measured by Tee-Tester occlusion pressure measurement after 1 week and 3 months，respectively. All patients received questionnaire survey after using for 3 months in each pair of dentures. Results The masticatory efficiency of the lingualized occlusion was slightly higher than the anatomic bilateral balanced occlusion，but there was no statistically significant difference. The occlusal force of the lingualized occlusion was less than the anatomic bilateral balanced occlusion and there was statistically significant difference. In the questionnaire，the patients gave a high evaluation on the complete denture of lingualized occlusion. Conclusion Compared with the complete denture of anatomic bilateral balanced occlusion，the complete denture of lingualized occlusion has higher stability，with the same masticatory efficiency and less occlusion pressure，which protects the alveolar ridge and delays the absorption of alveolar ridge.

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The influence of periodontal non-surgical therapy to the level of high sensitive C reactive protein in patients with periodontitis and coexistent coronary heart disease. ZHANG Xue-fei*，CHANG Chun-rong，PAN Ya-ping，HUANG Jie 2014, 7(3): 172-174.  Abstract ( )   PDF (845KB) ( )   Abstract： Objective To evaluate the influence of periodontal non-surgical treatment for serum and gingival crevicular fluid （GCF） high sensitive C-reactive protein （hs-CRP） level. We aimed to explore the role of periodontal therapy for reducing the risk of coronary heart disease （CHD） recurrence. Methods Totally 40 chronic periodontal patients with CHD were divided into two groups randomly. There are 25 patients in trial group receiving routine medical maintenance therapy （no antibiotic） and periodontal non-surgical treatment， and the other fifteen patients as the control，only receive routine medical maintenance therapy （no antibiotic）. The periodontal indexes in 2 groups were detected at the baseline and one month after the treatment. The levels of hs-CRP （immunity tarbidimetry） of serum and GCF were measured in the patients for two times. Results After one month of therapy， subjects in trial group presented with lower gingival plaque scores， lower numbers of PD （Probing Depth） when compared to control group. Lower levels of hs-CRP of serum and GCF were exhibited （P < 0.05）. Conclusion Periodontal therapy improves the body’s inflammatory state， reduce systemic inflammatory factors hs-CRP levels， and improve cardiovascular function.

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Research progress of bone tissue engineering scaffolds. XU Da-peng，WANG Xu-kai 2014, 7(3): 177-181.  Abstract ( )   PDF (874KB) ( )   Abstract： The tissue-engineered bone is a new approach for jaw defect repair treatment， research focus of which is to seek suitable scaffolds for cell transplantation and guiding the growth of new bone to act as substitutes of the extracellular matrix. These scaffolds are often porous， made of biodegradable materials that harbor different growth factors， drugs or stem cells. In this review， we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.

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Progress in application of total temporomandibular joint replacement. BAI Guo， HE Dong-mei， YANG Chi 2014, 7(3): 182-187.  Abstract ( )   PDF (891KB) ( )   Abstract：Total temporomandibular joint （TMJ） replacement has been clinically mature after nearly 50 years of development. It is mainly used for TMJ ankylosis， advanced stage of condylar osteoarthritis， condylar tumor and idiopathic condylar resorption. However， there is no related domestic product. In this article， main kinds of international total TMJ replacement systems were introduced including the design， types and clinical application.

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The application of titanium in prosthodontics. CHEN Xi-wen， ZHU Zhi-min 2014, 7(3): 188-192.  Abstract ( )   PDF (875KB) ( )   Abstract：The important role of pure titanium in oral medicine is beyond dispute.It’s widely applied in clinical treatment of stomatology. Specially， in oral restoration， due to its desired physical and chemical property， and its higher biocompatibility and mechanical strength， titanium has been used to fabricate many kinds of prosthesis， such as implant， framework， post and so on. Although it has been widely used， it’s significant for dentist to grasp the indications of titanium prosthesis. This review summarizes the properties of titanium and its application in prosthodontics. The purpose is to provide a reference for dental prosthesis design and selection of repair materials.