Abstract:

Abstract： Objective To evaluate the influence of periodontal non-surgical treatment for serum and gingival crevicular fluid （GCF） high sensitive C-reactive protein （hs-CRP） level. We aimed to explore the role of periodontal therapy for reducing the risk of coronary heart disease （CHD） recurrence. Methods Totally 40 chronic periodontal patients with CHD were divided into two groups randomly. There are 25 patients in trial group receiving routine medical maintenance therapy （no antibiotic） and periodontal non-surgical treatment， and the other fifteen patients as the control，only receive routine medical maintenance therapy （no antibiotic）. The periodontal indexes in 2 groups were detected at the baseline and one month after the treatment. The levels of hs-CRP （immunity tarbidimetry） of serum and GCF were measured in the patients for two times. Results After one month of therapy， subjects in trial group presented with lower gingival plaque scores， lower numbers of PD （Probing Depth） when compared to control group. Lower levels of hs-CRP of serum and GCF were exhibited （P < 0.05）. Conclusion Periodontal therapy improves the body’s inflammatory state， reduce systemic inflammatory factors hs-CRP levels， and improve cardiovascular function.

Key words: periodontitis, coronary heart disease, periodontal non-surgical treatment, hs-CRP

摘要：

目的 探讨牙周基础治疗对伴发冠心病的牙周炎患者外周血及局部超敏-C反应蛋白（ hs-CRP）水平的影响。方法 选择2007年2月至2011年9月来中国医科大学口腔医学院牙周病科就诊的慢性中、重度牙周炎并发冠心病（稳定期）患者40例。随机分为试验组（25例）和对照组（15例）。试验组患者接受内科维持治疗及牙周基础治疗，对照组患者仅接受内科维持治疗。两组患者分别在治疗前及治疗后1个月行牙周检查，检查指标为全口菌斑指数（PLI）、牙周探诊深度 （PD），并采集静脉血及龈沟液样本，检测其中hs-CRP的含量。结果 治疗前试验组与对照组间各牙周检查指标（PLI、PD）及静脉血和龈沟液中的hs-CRP含量差异均无统计学意义（P＞0.05）；经过1个月治疗，试验组各牙周检查指标（PLI、PD）及静脉血和龈沟液中的hs-CRP含量均明显低于对照组，差异有统计学意义（P < 0.05）；试验组治疗前后疗效对比结果显示，各牙周检查指标（PLI、PD）及静脉血和龈沟液中的hs-CRP含量均有明显的降低，差异有统计学意义（P < 0.05）。结论 牙周基础治疗可改善机体的炎症状态，减少全身炎性因子hs-CRP的含量，降低冠心病再发的风险。

关键词: 牙周炎, 冠心病, 牙周基础治疗, 超敏C-反应蛋白