Abstract: Anti-cardiolipin antibody（ACA）is an autoimmune antibody associated with thrombus formation and thrombocytopenia，which is affected by bacterial infection. Periodontitis is a chronic infectious disease in which plaque microorganisms trigger host immune response and produce inflammatory mediators leading to periodontal tissue destruction. Current researches have found that periodontal pathogens in patients with periodontitis lead to the increase of serum ACA level through the mechanism of "molecular simulation"，while periodontal basic treatment leads to the decrease of serum ACA level，which mediates periodontal inflammation through the regulation of inflammatory factors. This paper reviews the research progress in the correlation between periodontitis and ACA and its mechanism.

Key words: periodontitis；anticardiolipin antibody, ACA；pathogenesis

摘要： 抗心磷脂抗体（anti-cardiolipin antibody，ACA）是与血栓形成、血小板减少有关的自身免疫抗体，受细菌感染因素影响。牙周炎是一种慢性感染性疾病，通过菌斑微生物引发宿主免疫反应产生炎症介质导致牙周组织破坏。目前研究发现，牙周炎患者的牙周致病菌可通过“分子模拟”机制导致血清ACA水平升高，牙周基础治疗可使血清ACA水平降低，ACA可通过调控炎性因子介导牙周炎症。文章就牙周炎与ACA相关性及其机制的研究进展做一综述。

关键词: 牙周炎, 抗心磷脂抗体, 发病机制