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02 October 2016, Volume 32 Issue 10 Previous Issue    Next Issue

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Lay emphasis on the perinatal management of autoimmune disease. LIN Qi-de. 2016, 32(10): 921-923.  DOI: 10.7504/fk2016090101 Abstract ( )   Abstract：Autoimmune disease is a situation of immune disorder, and realizing the interaction between pregnancy and autoimmune disease and taking effective measures during perinatal stage is essential to ensure a successful delivery. In brief, we should set up multi-disciplinary teams, do some special tests and make individualized drug treatment, make plans before pregnancy, attach importance to prenatal examinations, enhance fatal and placental monitoring, terminate pregnancy in a proper time and make managements during puerperium stage.

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Perinatal management of pregnant women with systemic lupus erythematosus. LI Jing, LUO Man-ling, ZHONG Mei. 2016, 32(10): 934-939.  DOI: 10.7504/fk2016090104 Abstract ( )   Abstract:Systemic lupus erythematosus （SLE） pregnancy is a high risk pregnancy with high fetal loss rate and adverse pregnancy outcomes. It will improve the pregnancy outcome to select the appropriate timing of pregnancy, perform rational use of drugs during pregnancy, monitor the mother and children closely, terminate pregnancy in time, and to standardize and strengthen the management of pregnancy in patients with SLE.

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Influence of pregnancy complicated with rheumatoid arthritis on mothers and fetuses and its diagnosis and treatment. HUANG Shu-hui，LIU Huai. 2016, 32(10): 939-942.  DOI: 10.7504/fk2016090105 Abstract ( )   Abstract:Rheumatoid arthritis is a kind of autoimmune disorder. The improvement of RA during pregnancy can be attributed to not just a single mechanism but most likely several different pathogenic mechanisms. The use of medication is restricted and should be based on activity of RA and the risk for embryotoxicity and teratogenicity in the offspring should be avoided.Increasing evidence is available on the safe use of NSAIDs,SSZ,HCQ and TNF inhibitors in pregnancy,which can be used in the treatment of pregnancy with RA.

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Effect of pregnancy with Sjögren’s syndrome on mothers and fetuses and the management during pregnancy. HE Jing，CAI Shu-ping. 2016, 32(10): 942-945.  DOI: 10.7504/fk2016090106 Abstract ( )   Abstract:Sjögren’s syndrome is a major chronic inflammatory autoimmune disease involving systemic exocrine glands. The prognosis of this disease is good in general , but during the pregnancy it may lead to miscarriage, premature birth, IUGR and increasing cesarean section rate, and can also lead to fetal congenital atrioventricular block, neonatal lupus and neonatal blood diseases. The author made a systematic discussion on the interaction between Sjögren’s syndrome and pregnancy ,and key points of management system in this paper.

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Effect of myasthenia gravis on pregnancy and its management. SONG Yi-jun, LIU Jun-tao. 2016, 32(10): 945-948.  DOI: 10.7504/fk2016090107 Abstract ( )   Abstract: Myasthenia gravis is an autoimmune disease of the neuromuscular junction characterized by skeletal muscle weakness. Disease exacerbations are more likely to occur in the first trimester or puerperium. A number of medications commonly used in obstetric practice can exacerbate the disease. The effect of myasthenia on pregnancy varies substantially from woman to woman and also from pregnancy to pregnancy in the same woman. Mainstay treatments involve acetylcholine esterase inhibitors, corticosteroids and other immunosuppressants, and adequate rest. Newborns may suffer, usually transient, which is due to transplacental antibody exposure in utero.

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Diagnosis and treatment of pregnancy complicated with antiphospholipid syndrome. SHI Jun，ZHAO Ai-min. 2016, 32(10): 948-952.  DOI: 10.7504/fk2016090108 Abstract ( )   Abstract: Antiphospholipid syndrome is the non-inflammatory autoimmune disease caused by antiphospholipid antibodies. In the pregnancy with APS, the following may occur: recurrent spontaneous abortion in the first trimester, intrauterine fetal death in the third trimester, fetal growth restriction, thrombocytopenia, preeclampsia or eclampsia, placental dysfunction and other adverse pregnancy outcome. All these will do great harm to the health of mothers and fetuses.We should pay more attention to the diagnosis and treatment of obstetric APS.

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Impact of idiopathic thrombocytopenic purpura in pregnancy on the pregnant women and fetuses and its diagnosis and treatment. CHEN Xu, JIA Yan-ju. 2016, 32(10): 952-956.  DOI: 10.7504/fk2016090109 Abstract ( )   Abstract: The pathophysiology of ITP is complicated and the onset of ITP is progressing slowly. The clinical features of ITP are similar to those of the other diseases leading to thrombocytopenia, the differential diagnosis is often difficult. The treatment in the perinatal period is very important because if it is treated improperly, the mother and fetus will be endangered. In recent years, although the study of ITP has been greatly developed，and many countries have developed the guidelines and consensus on how to manage ITP , but there is still controversy about the ideal strategy of diagnosis and treatment of ITP in pregnancy. This paper focused on elaborating the clinical manifestations, the impact on the pregnant women and fetuses, diagnosis, differential diagnosis and the treatment progress of ITP in pregnancy by reviewing recent literatures.

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Screening and treatment of pregnancy-associated autoimmune thyroid disease. SUN Li-zhou，GE Zhi-ping. 2016, 32(10): 956-959.  DOI: 10.7504/fk2016090110 Abstract ( )   Abstract: Autoimmune thyroid disease is one of the commonest disease in pregnancy women．Several researches have found out that thyroid antibody positivity is related to miscarriage, preterm birth, infertility, placental abruption, perinatal mortality and postpartum thyroiditis．The early detection of the thyroid function and antibodies before and during pregancy is important for clinical intervention.This article summarizes the latest progress in screening and treatment of pregnancy-associated autoimmune thyroid disease, hoping to offer guidance for the clinician.

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Influence of pregnancy complicated with autoimmune type 1 diabetes mellitus on mothers and fetuses and its diagnosis and treatment. XU Xian-ming,LI Fei-fei . 2016, 32(10): 959-963.  DOI: 10.7504/fk2016090111 Abstract ( )   Abstract: Autoimmune type 1 diabetes mellitus is one of the common complications during pregnancy, which can lead to increased maternal and fetal complications.This paper presents the screening and diagnostic standards for pregnant women with autoimmune type 1 diabetes mellitus, and proposes that adequate preparation before pregnancy, intensive monitoring during pregnancy and excellent glycaemic control throughout the pregnancy by diet control and insuline injection can reduce maternal and fetal complications , which improves the outcome of pregnancy.

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Diagnosis and treatment of autoimmune hepatitis complicating pregnancy and its influence on mothers and fetuses. FAN Ling,ZHOU Li. 2016, 32(10): 963-966.  DOI: 10.7504/fk2016090112 Abstract ( )   Abstract: During pregnancy, most of autoimmune hepatitis (AIH) patients can maintain stable or even be relieved, but they are prone to have recurrence after delivery，and some of them may develop liver fibrosis, liver cirrhosis, and even hepatic coma.The occurrence rate of adverse pregnancy outcomes in AIH patients increased, such as premature birth, abortion and so on. AIH patients during pregnancy should continue to maintain prednisone treatment at a minimum dose according to the doctor’s guidance. AIH patients at pregnancy need to be closely followed up during pregnancy and postpartum by the obstetricians and hepatologists.