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02 September 2016, Volume 32 Issue 9 Previous Issue    Next Issue

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Deficiency of neoadjuvant chemotherapy in the treatment of gynecological malignancy. JIANG Fang， XIANG Yang. 2016, 32(9): 828-831.  DOI: 10.7504/fk2016080102 Abstract ( )   Abstract:Neoadjuvant chemotherapy （NACT） was introduced to the treatment of gynecological malignancy in 1980s.Researches have shown that NACT is helpful to improve the general condition of patients，destroy the distant metastases，reduce tumor volume and，thus，improve the perioperative outcomes and increase the success rate of cytoreductive surgery.However，the therapeutic benefit of neoadjuvant chemotherapy remains controversial.A major criticism is that neoadjuvant chemotherapy fails to prove definite benefit on survival.In this article，we will discuss the limitations and deficiency of NACT in the treatment of gynecologic malignancy.

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Efficacy of neoadjuvant chemotherapy in the treatment of advanced endometrial carcinoma. LIU Chan-zhen, ZHANG Jie-qing,LI Li. 2016, 32(9): 831-834.  DOI: 10.7504/fk2016080103 Abstract ( )   Abstract: Advanced endometrial carcinoma is difficult to be managed successfully in primary cytoreductive surgery, and its prognosis is poor.Chemotherapy is the main treatment for advanced endometrial carcinoma .The role of chemotherapy in advanced endometrial carcinoma is currently the focus of the researchers.This review analyzes and summarizes the efficacy and regimens of neoadjuvant chemotherapy so that rational treatment strategies can be made.

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Combination treatment of neoadjuvant chemotherapy with radiation for locally advanced cervical cancer. ZHANG Shi-qian，WANG Wen. 2016, 32(9): 834-837.  DOI: 10.7504/fk2016080104 Abstract ( )   Abstract: Platinum-based concurrent chemoradiotherapy in the NCCN guidelines is considered as a standard treatment for locally advanced cervical carcinoma. Nevertheless, other treatment modalities with similar efficacy have been developed in such regions Europe, Japan, South Korea, and Latin America. Because of the different levels of medical institutions and radiotherapy equipment in China, neoadjuvant chemotherapy combined with radiotherapy or chemoradiation can yet be regarded as an alternative method. The role of surgery can’t be ignored in the treatment of locally advanced cervical cancer, and neoadjuvant chemotherapy is only one part of the comprehensive treatment for locally advanced cervical cancer，so clinical applications should be careful. NACT can’t be regarded as a single and primary treatment.

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Neoadjuvant chemotherapy for cervical cancer in pregnancy. LI Xiao-ping，ZONG Xiao-nan. 2016, 32(9): 838-841.  DOI: 10.7504/fk2016080105 Abstract ( )   Abstract: The incidence rate of cervical cancer in pregnancy is about 1/10000.According to tumor types，clinical stage，gestational weeks and the wishes of patients to continue pregnancy，it is recommended to take cisplatin-basedmonotherapy or combined neoadjuvant chemotherapy regimens until the fetus reaches maturity.Neoadjuvant chemotherapy （NACT） is an innovative approach in the management of these patients，and it does not significantly increase the risk of birth defects，but long-term concern should be given to the impact onthe mother and baby's health.

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Acquisition methods of pathological evidence before neoadjuvant chemotherapy for ovarian cancer. LI Xiao，LIN Bei. 2016, 32(9): 841-844.  DOI: 10.7504/fk2016080106 Abstract ( )   Abstract: Neoadjuvant chemotherapy showed an advantage in the treatment of patients with advanced ovarian cancer。It is particularly important to obtain pathological evidence before neoadjuvant chemotherapy. Currently，abdominal fine needle aspiration biopsy，transvaginal fine needle aspiration biopsy，lymph node biopsy，pleural effusion or peritoneal cytology，laparoscopic biopsy and laparotomy biopsy were used in clinical work. The purpose of this article is to describe the methods mentioned above and discuss their advantages and disadvantages.

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Neoadjuvant chemotherapy in vulvar cancer: current status and future diretions. LIN Zhong-qiu,WANG Li-juan,LI Rui-xin. 2016, 32(9): 845-848.  DOI: 10.7504/fk2016080107 Abstract ( )   Abstract: Management of locally advanced vulvar cancer remains a significant challenge.Recent studies have shown that neoadjuvant chemotherapy (NACT) with bleomycin and platinum followed by surgery has resulted in good effect and tolerable side effects.Two to three cycles of NACT may induce tumor regression，preserve organ function and improve prognosis.As a potential alternative for patients with locally advanced vulvar cancer，this treatment modality needs further validation to confirm its effects.

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The advantage and disadvantage of intra-arterial and intravenous neoadjuvant chemotherapy for locally advanced cervical cancer. CHEN Chun-lin. 2016, 32(9): 848-852.  DOI: 10.7504/fk2016080108 Abstract ( )   Abstract: The performance of neoadjuvant chemotherapy for treating locally advanced cervical cancer was still needed to exist according to our country.But it was controversy about the approach of chemotherapy.The history of intra-arterial chemotherapy was longer than intravenous chemotherapy which only developed in the last decade due to the emergence of new effective anticancer drugs.Intraarterial chemotherapy can increase the drugs' dosage in a short time and reduce tumor volume effectively.That was the foundation for the subsequent surgical treatment.This article was aided to understand the advantages and disadvantages of two neoadjuvant chemotherapy's approach through discussing the history, mechanism, efficacy and economic benefits.

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Application value of laparoscopic exploration in the primary surgery for advanced ovary cancer. LIU Ji-hong*, TU Hua*, YAO Shu-zhong, YUAN Lin-jing. 2016, 32(9): 852-855.  DOI: 10.7504/fk2016080109 Abstract ( )   Abstract: The primary management of advanced ovarian cancer is an individualized decision-making process. Laparoscopy provides an insight into disease distribution for individuals, by which the performance of subsequent debulking surgery can be determined. However, despite the theoretical feasibility and some supportive studies, there exist some limitations hindering the use of laparoscopy in determining whether to be able to reach optimal cytoreduction for each patient with advanced ovarian cancer. Hence, the clinical value of this procedure remains to be demonstrated by further investigations.

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The value of neoadjuvant chemotherapy followed by fertility sparing treatment in patients with cervical cancer. HOU Jian-qing，JIANG Hai-yang. 2016, 32(9): 855-859.  DOI: 10.7504/fk2016080110 Abstract ( )   Abstract: The age of patients with cervical cancer is getting younger and younger.Proportion of patients who don’t have a birth is increasing.Fertility sparing surgery has become a standard treatment for the patients with early stage cervical cancer.But the indications are strict，the benifits are limit.Neoadjuvant chemotherapy can enlarge the indication of such the operation and reach the purpose of fertility，it have no adverse effect on the pregnancy.