Abstract:

Abstract: Management of locally advanced vulvar cancer remains a significant challenge.Recent studies have shown that neoadjuvant chemotherapy (NACT) with bleomycin and platinum followed by surgery has resulted in good effect and tolerable side effects.Two to three cycles of NACT may induce tumor regression，preserve organ function and improve prognosis.As a potential alternative for patients with locally advanced vulvar cancer，this treatment modality needs further validation to confirm its effects.

Key words: vulvar cancer, neoadjuvant chemotherapy, prognosis

摘要：

局部晚期外阴癌患者的处理较为棘手。近年来针对这部分患者进行新辅助化疗后行手术治疗的研究显示，以博来霉素和铂类药物为主的多种化疗方案反应率较好，不良反应可耐受。化疗2~3个疗程后手术，可缩小手术范围，保留器官功能，提高生存率。但仍需更深入的研究评价其效果及最佳治疗方案。

关键词: 外阴肿瘤, 新辅助化疗, 预后