Abstract:Sjögren’s syndrome is a major chronic inflammatory autoimmune disease involving systemic exocrine glands. The prognosis of this disease is good in general , but during the pregnancy it may lead to miscarriage, premature birth, IUGR and increasing cesarean section rate, and can also lead to fetal congenital atrioventricular block, neonatal lupus and neonatal blood diseases. The author made a systematic discussion on the interaction between Sjögren’s syndrome and pregnancy ,and key points of management system in this paper.