Abstract:Rheumatoid arthritis is a kind of autoimmune disorder. The improvement of RA during pregnancy can be attributed to not just a single mechanism but most likely several different pathogenic mechanisms. The use of medication is restricted and should be based on activity of RA and the risk for embryotoxicity and teratogenicity in the offspring should be avoided.Increasing evidence is available on the safe use of NSAIDs,SSZ,HCQ and TNF inhibitors in pregnancy,which can be used in the treatment of pregnancy with RA.