Abstract:

Consideration of anticancer therapeutic agents in early gastric cancer　　LIU Yi-lin， ZHANG Xiao-tian.Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China
Corresponding author：Zhang Xiao-tian, E-mail: zhangxiaotianmed@163.com
Abstract　Early gastric cancer is mainly treated withradical resection by either endoscopic resection or radical surgery. but there arestill patients  finally developrecurrence and metastasis. There are arguments on how to identify these patients with poor prognosis，and how to manage the treatment，and the value and timing ofanticancer therapeutic agents. Because of low level of evidence, the current clinical guidelines are relatively vague on these questions, and oncologists differ in treatment optionin real world. The role of anticancer therapeutic agents in early gastric cancer needs to be re-examined given the advances in molecular biology,bioinformatics and new drugs.

Key words: early gastric cancer, recurrence, anticancer therapeutic agents

摘要：

早期胃癌以局部治疗为主，包括内镜下切除或根治性手术，但仍有病人术后发生复发转移。对于此类病人如何甄别，如何管理，药物治疗的价值和时机均存在较大争议。临床指南相关规定比较含糊，证据级别不高。临床实践的实际处理策略也存在较大差异。基于目前分子生物学和生信学的进步，随着新药物的研发及上市，药物治疗在早期胃癌中的地位和作用有待重新审视。

关键词: 早期胃癌, 复发, 抗肿瘤药物