Abstract:

Diagnosis and clinical significance of positive peritoneal lavage cytology in gastric cancer surgery        LI Zi-yu, MIAO Ru-lin, JI Jia-fu. Center of Gastrointestinal Tumors, Peking University School of Oncology, Beijing Cancer Hospital & Institute; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China
Corresponding author: LI Zi-yu, E-mail:ligregory@outlook.com
Abstract    Positive peritoneal lavage cytology is a particular type of late stage gastric cancer that indicates the early pattern of peritoneal metastasis. Currently, the main diagnostic method of peritoneal lavage cytology is the laparoscopic exploration combined with peritoneal lavage examination, and many molecular diagnostic methods have been applied while lack of standardization. Positive peritoneal lavage cytology is a negative prognostic factor and treatments as systemic therapy and peritoneal local control that turn the positive cytology to negative can lead to survival benefit to the patients. More high quality RCTs are still needed to explore the standard methods of diagnosis and treatment to achieve the goal of standardization, personalization and specialization.

Key words: gastric cancer, peritoneal lavage cytology, peritoneal local treatment, preoperative chemotherapy

摘要：

胃癌并腹腔游离癌细胞是一种特殊类型的晚期胃癌，是腹腔转移的早期表现形式。目前，腹腔游离癌细胞的检测主要通过腹腔镜探查联合腹腔灌洗细胞学检查进行。诸多分子生物学检测方法也开始出现，但是仍缺乏相关统一规范。腹腔游离癌细胞阳性病人预后较差，而通过全身系统治疗、腹腔局部治疗等使腹腔游离癌细胞转阴后可能为病人带来生存获益。目前，仍需要高质量的前瞻性随机对照研究对腹腔游离癌细胞的检测和治疗方法进行评估，以达到诊断、治疗的规范化、个体化和专业化。

关键词: 胃癌, 腹腔游离癌细胞, 腹腔局部治疗, 术前化疗