中国实用外科杂志

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肝脏精细解剖学与手术策略的改进和创新

樊    嘉,王晓颖   

  1. 复旦大学附属中山医院肝胆肿瘤与肝移植外科 复旦大学肝癌研究所,上海 200032
  • 出版日期:2025-08-01

  • Online:2025-08-01

摘要: 近年来,随着高分辨率影像学、三维可视化、吲哚菁绿荧光成像、虚拟现实、增强现实等技术的发展,肝脏解剖学已从传统的大体形态描述迈向个体化、微观化、功能化等多维度精细解剖时代。肝脏精细解剖学最新进展及其对手术策略的革新作用包括:(1)从Couinaud分段到基于亚肝段的个体化流域切除的演变。(2)肝内解剖间隙的再认识。(3)从静态解剖到动态流域,利用交通支预调控流域保留肝实质,阻断交通支产生联合肝脏分隔和门静脉结扎的二步肝切除术、肝静脉剥夺术等新术式。(4)功能与形态的结合,通过SPECT、MRI肝胆特异性对比剂等技术评估区域肝功能。(5)分子影像技术精准界定肿瘤侵袭边界,降低非解剖性切除时切缘阳性率。(6)人工智能(AI)对精细解剖及手术创新的促进。未来,随着AI、分子影像学和肝脏血流动力学研究的深入,肝脏外科将进一步向精准化、功能化和智能化发展,为复杂肝肿瘤病人提供更安全、更有效的个体化治疗方案。

关键词: 肝脏外科, 解剖学, 肝切除术

Abstract: In recent years, with the development of high-resolution imaging, three-dimensional visualization, indocyanine green fluorescence imaging, virtual reality, and augmented reality, liver anatomy has advanced from traditional macroscopic morphological description to a multi-dimensional era of individualized, microscopic, and functional fine anatomy. The latest progress in liver fine anatomy and its innovative role in surgical strategies include: (1) the evolution from Couinaud’s segmentation to individualized watershed resection based on sub-segments; (2) the re-recognition of intrahepatic anatomical spaces; (3) the transition from static anatomy to dynamic watersheds, the development of two-step hepatectomy with combined liver partition and portal vein ligation, and hepatic vein deprivation, which utilize shunt vessels to pre-regulate the watershed and preserve liver parenchyma; (4) the integration of function and morphology, the assessment of regional liver function through SPECT, MRI hepatobiliary-specific contrast agents, and other techniques; (5) the precise demarcation of tumor invasion boundaries by molecular imaging technology to reduce the positive margin rate in non-anatomical resection; (6) the promotion of fine anatomy and surgical innovation by artificial intelligence (AI). In the future, with the in-depth research of AI, molecular imaging, and hemodynamics, liver surgery will further develop towards precision, functionality, and intelligence, providing safer and more effective individualized treatment plans for patients with complex liver tumors.

Key words: liver surgery, anatomy, hepatectomy