Abstract:

Disseminated intravascular coagulation（DIC）is one of the major etiologies behind the pathological change of amniotic fluid embolism（AFE）.The depletion of coagulation factor and the damage of red blood cell  were common manifestations of DIC，which can also promote the formation of pulmonary hypertension.Meanwhile，DIC is also the main reason of hemorrhage of AFE.The detection of DIC at an early stage facilitates the clinical diagnosis of AFE.Preventing procoagulants from getting into the maternal circulation and anticoagulant therapy may be profitable to prevent the deterioration of DIC.Heparin should be both employed at the stage of hypercoagulation and the early stage hypocoagulation .Simultaneously，the supplement of coagulation factor is also crucial.The change of coagulation function must be closely monitored.

Key words: amniotic fluid embolism, disseminated intravascular coagulation, heparin, treatment

摘要：

弥散性血管内凝血（disseminated intravascular coagulation，DIC）是羊水栓塞（amniotic fluid embolism，AFE）病理改变的重要原因之一。DIC造成大量凝血因子消耗和红细胞破坏，并加重肺动脉高压，也是AFE出血的主要原因。早期发现DIC，有助于AFE的诊断。减少促凝物质进入血液循环、抗凝治疗可阻断DIC的进一步发展。肝素应在DIC高凝期或低凝期早期使用，同时需补充凝血因子，监测凝血功能的变化。

关键词: 羊水栓塞, 弥散性血管内凝血, 肝素, 治疗