Special pathological types of gestational trophoblastic neoplasia mainly include placental site trophoblastic tumour（PSTT）and epithelioid trophoblastic tumour（ETT），which belong to intermediate-type trophoblastic tumors. The diagnosis is relatively difficult because of the lack of specific clinical manifestations and sensitive tumor markers. Surgery is the mainly primary treatment；hysterectomy is performed for localized disease in uterus and surgical resection can be carried out for resectable lesions if there is extra-uterine invasion or metastasis. The adjuvant chemotherapy plan is made according to the factors of poor prognosis. Most patients are young and have the desire of fertility preservation，the treatment of retaining reproductive function can be implemented for suitable patients with lesion limited to uterus. Due to poor sensitivity of PSTT and ETT to chemotherapy，drug resistance is a most important factor of  poor prognosis. There is still a lack of randomized controlled trials to guide clinical treatment because of the low incidence，and new treatments such as targeted therapy amd immunotherapy are also constantly explored.