The hydatidiform mole is the most common gestational trophoblastic disease，and according to heredity，histopathological features and clinical manifestations：hydatidiform mole can be divided into two types，complete hydatidiform mole and partial hydatidiform mole. In addition, there are three special types：recurrent hydatidiform mole, familial hydatidiform mole，and one complete hydatidiform mole in a twin gestation. This article will introduce the etiology，clinical diagnosis，treatment，follow-up and special types of hydatidiform mole in order to improve the standardized diagnosis and treatment of this disease.