Placental ischemia and placental abruption.

doi:10.7504/fk2016030106

Abstract

Abstract:

Abstract: Placental abruption is one of the most important causes of maternal morbidity and perinatal mortality. The initial event leading to placental abruption is thought to be an ischemic lesion of the decidua, resulting in decidual necrosis, vascular disruption and bleeding. In the event of hemorrhage, laceration and dissection along a decidual plane and placental separation occur. The latter produces more vascular disruption, arterial hemorrhage and retroplacental accumulation of blood, which leads to placental abruption at last.

Key words: spiral artery, trophoblast, oxidative stress

摘要：

胎盘早剥是是妊娠晚期的严重并发症之一，处理不当可危及母儿生命。胎盘的缺血性损伤被认为是胎盘早剥的最初原因。胎盘缺血性损伤导致了滋养细胞侵袭能力的改变及子宫螺旋小动脉发生的重塑障碍，胎盘缺血、缺氧后释放各种细胞因子造成蜕膜坏死、血管破裂、出血，而出血导致底蜕膜和胎盘之间形成撕裂和分离，进而造成蜕膜板和胎盘的分离。进一步造成更多的血管破裂、动脉出血和胎盘后血肿，最后导致胎盘早剥的发生。

关键词: 螺旋动脉, 滋养细胞, 氧化应激

CLC Number:

R714.43

LI Lei, LIAN Yan, WANG Xie-tong. Placental ischemia and placental abruption.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2016030106.

李磊，连岩，王谢桐. 胎盘缺血与胎盘早剥[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2016030106.

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