All patients with refractory gestational trophoblastic neoplasia （GTN） require re-assessment of the extent of disease before initiating another treatment. Salvage chemotherapy with multiagent combination is still the main treatment option at present. For the patients with resectable lesions，it is crucial to perform a complete surgical excision of tumors simultaneously during salvage chemotherapy. In addition，these patients may also benefit from the emerging immunotherapy. After remission is achieved，serum human chorionic gonadotrophin （hCG） should be monitored regularly in a long term.