Gestational trophoblastic neoplasia （GTN） is a subsequent disease to pregnancy. Although it is highly sensitive to chemotherapy，some patients still died of drug resistance and relapse. Since the disease origin is closely related to immunity，immunotherapy has shown initial success in refractory GTN. With the deepening of the research on emerging immune targets，immunotherapy has gradually become the focus of GTN salvage therapy in recent years. This review will focus on the research progress about immunotherapy for GTN.