Gestational trophoblastic diseases include non-neoplastic hydatidiform mole（HM）and neoplastic lesions，including choriocarcinoma，placental site trophoblastic tumor and epithelioid trophoblastic tumor. With the development of researches in this field，some new disease subtypes have been discovered，such as familial recurrent HM and complete HM in a twin gestation. Some molecular diagnostic methods have also been developed，such as p57 immunohistochemical staining and short tandom repeat（STR）genotyping，making the pathological diagnosis more accurate than the previous morphology-based diagnosis，and more reflective of the process of carcinogenesis. In this review，based on the latest articles and WHO Classification of Female Genital Tumors，we summarized the pathological features and the molecular diagnostic methods of such diseases.