Abstract: It remains a critical point in clinical research to improve severe adverse neurodevelopmental outcomes caused by hypoxic-ischemic encephalopathy（HIE）. Artificial Intelligence（AI）is increasingly demonstrating advantages in neonatal HIE management，including early therapeutic decision-making，prediction of long-term prognosis，development of precision rehabilitation protocol，and the application of telemedicine. AIpowered approaches are expected to redefine traditional diagnostic and therapeutic paradigms and significantly improve adverse neurodevelopmental outcomes of HIE. However，AI-based diagnostic and therapeutic paradigms of HIE will bring benefits to HIE children， but further clinical data is needed in terms of the concomitant safety risks and broad applicability in various situations.

Key words: hypoxic-ischemic encephalopathy, neonate, artificial intelligence, rehabilitation, neurodevelopment

摘要： 改善缺氧缺血性脑病（hypoxic-ischemic encephalopathy，HIE）导致的严重不良神经发育结局是临床研究的热点问题。人工智能（artificial intelligence，AI）技术在新生儿HIE的早期治疗决策、远期预后判断、精准康复方案的制定和远程医疗上的优势日渐凸显。AI赋能将重塑HIE的诊疗思维模式、极大改善不良神经发育结局。基于AI的HIE诊疗模式将给患儿带来临床获益，其伴随的安全风险、多场景适用性有待更多临床数据支撑。

关键词: 缺氧缺血性脑病, 新生儿, 人工智能, 康复, 神经发育