Abstract: The incidence of inflammatory bowel disease （IBD（) in children is increasing and shows characteristics such as a younger age of onset and difficulty in treatment. Biologics have shown good efficacy in adult IBD patients, and their use in the treatment of pediatric IBD has become increasingly widespread in recent years. Understanding the indications, contraindications, timing, and regimen of biologic therapy for pediatric IBD, as well as efficacy evaluation, medication risks, cessation strategies, and follow-up management, can help avoid risks and benefit patients as much as possible. This article will discuss the use of biologics in the treatment of pediatric IBD.

Key words: inflammatory bowel disease, pediatric, biologics, treatment

摘要： 儿童炎性肠病（inflammatory bowel disease，IBD）的发生率不断上升，并且表现出低龄化、难治性等特点。生物制剂在成人IBD患者中显示出良好的疗效，近年来在儿童IBD治疗中的应用也越来越广泛。了解生物制剂治疗儿童IBD的适应证、禁忌证、用药时机与方案、疗效评估、用药风险、停药策略、随访管理等，尽可能规避风险，才能帮助患者更好地获益。现就生物制剂在儿童IBD的应用进行阐述。

关键词: 炎性肠病, 儿童, 生物制剂, 治疗