Abstract: Hereditary spastic paraplegia（HSP）is a group of rare neurodegenerative diseases caused by a single gene defect，which mainly manifests as progressive muscle weakness and spasticity of the lower extremities. HSP is classified according to genetic，phenotypic and molecular pathophysiological mechanisms.Although genetic testing is widely available，there are still limitations，and molecular diagnosis cannot be made in most suspected cases. Current treatments help manage the disease，but treatment outcomes remain unsatisfactory. This article aims to review the research progress of clinical diagnosis，treatment and rehabilitation of HSP.

Key words: hereditary spastic paraplegia, diagnosis, treatment, rehabilitation

摘要： 遗传性痉挛性截瘫（HSP）是一组单基因缺陷导致的罕见的神经退行性疾病，主要表现为下肢进行性肌力减退和肌肉痉挛。HSP根据遗传、表型和分子病理生理机制进行分类。虽然基因检测已广泛使用，但仍有局限性，在大多数疑似病例中不能进行分子诊断。目前的治疗措施有助于管理这种疾病，但治疗结果仍不能令人满意。文章旨在对HSP的临床诊断、治疗及康复研究进展进行综述。

关键词: 遗传性痉挛性截瘫, 诊断, 治疗, 康复