中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (5): 372-376.DOI: 10.19538/j.ek2025050604

• 专题笔谈 • 上一篇    下一篇

儿童及青少年白癜风流行病学与发病机制

  

  1. 首都儿科研究所附属儿童医院皮肤一科，北京  100020
  • 出版日期:2025-05-06 发布日期:2025-08-28
  • 通讯作者: 高莹，电子信箱：sccgcw@sina.com
  • 基金资助:
    北京市中医药科技发展资金项目（BJZYYB-2023-20）；首都儿科研究所重点项目（LCYJ-2025-35）

Epidemiological characteristics and pathogenic mecha-nisms of vitiligo in children and adolescents

  1. Department of Dermatology，Children’s Hospital Affiliated to Capital Institute of Pediatrics，Beijing  100020，China
  • Online:2025-05-06 Published:2025-08-28

摘要： 流行病学研究显示，白癜风在儿童及青少年群体中的患病率为0.04%～2.16%，主要发生在3～8岁。儿童白癜风疾病的发病机制涉及自身免疫反应、遗传易感性及氧化应激等方面。此外，环境因素如日晒和化学物质接触，以及微量营养素的缺乏也与白癜风的发病密切相关。总体而言，儿童及青少年白癜风的发病机制复杂，需深入研究以开发针对该人群的有效治疗方案，以应对其与成人在治疗反应上的差异。

关键词: 儿童, 白癜风, 流行病学, 发病机制

Abstract: Epidemiological studies indicate that the preva-lence of vitiligo among children and adolescents ranges from 0. 04% to 2. 16%，who are aged primarily from 3 to 8 years old. The pathogenesis of vitiligo in children involves autoimmune responses，genetic susceptibility，and oxidative stress. Additionally，environmental factors such as sun exposure and contact with chemical substances，as well as deficiency in micronutrients，are closely associated with the onset of vitiligo. Overall，the pathogenesis of vitiligo in children and adolescents is complex，necessitating further research to develop effective treatment strategies tailored to this population，in order to address the differences in treatment responses from adults.

Key words: child, vitiligo, epidemiology, pathogenic mechanism