中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (6): 479-482.DOI: 10.19538/j.ek2025060607

• 专题笔谈 • 上一篇    下一篇

幽门螺杆菌感染的再认识：从基础研究到临床实践

  

  1. 广州医科大学附属妇女儿童医疗中心消化科  国家儿童医疗区域中心（中南），广东  广州  510120
  • 出版日期:2025-06-06 发布日期:2025-08-29
  • 通讯作者: 耿岚岚，电子信箱：13622237569@163.com
  • 基金资助:
    广州市临床重点专科（临床医学研究所） 广州市卫生健康委员会建设项目（基金编号：011009003）

Re-understanding of Helicobacter pylori infection：from basic research to clinical practice

  1. Guangzhou Women and Children’s Medical Center，Guangzhou Medical University；National Children’s Medical Regional Center （Central-South China）. Guangzhou  510120，China
  • Online:2025-06-06 Published:2025-08-29

摘要： 幽门螺杆菌（helicobacter pylori，Hp）感染是消化性溃疡和胃炎的主要原因，也与胃癌的发生密切相关，全球每年因幽门螺杆菌感染导致新发胃癌约80万例。近年来，Hp致胃癌机制研究有了深入的进展，筛查与根除策略在胃癌高发地区显示了有效的预防作用。耐药率持续上升，促使了新药及新治疗方案的诞生。在治疗指征的扩大化方面存在争议。文章结合最新研究进展，从基础到临床多角度探讨 Hp感染的关键问题，旨在为临床实践和公共卫生决策提供参考。

关键词: 幽门螺杆菌, 胃癌, 耐药性, 儿童

Abstract: Helicobacter pylori infection is the main cause of peptic ulcer and gastritis， and is closely related to the occurrence of gastric cancer. Every year， approximately 800 000 new cases of gastric cancer are caused by Helicobacter pylori infection worldwide. In recent years， the research in mechanism of Hp induced gastric cancer has made significant progress， and screening and eradication strategies have shown effective preventive effects in areas with high incidence of gastric cancer. The continuous increase in drug resistance rates has led to the emergence of new drugs and treatment plans. There is controversy over the expansion of treatment indications. Based on the latest research progress， this article explores the key issues of Hp infection from multiple perspectives， from basic to clinical， aiming to provide reference for clinical practice and public health decision-making.

Key words: Helicobacter pylori, gastric cancer, drug resistance, child