中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (6): 482-487.DOI: 10.19538/j.ek2025060608

• 专题笔谈 • 上一篇    下一篇

儿童小肠细菌过度生长的诊断与治疗

  

  1. 国家儿童医学中心  首都医科大学附属北京儿童医院消化科，北京  100045
  • 出版日期:2025-06-06 发布日期:2025-08-29
  • 通讯作者: 秦秀敏，电子信箱：qinxiumin0418@126.com

Diagnosis and treatment of pediatric small intestinal bacterial overgrowth

  1. Department of Gastroenterology，Beijing Children’s Hospital of Capital Medical，Beijing  100045，China
  • Online:2025-06-06 Published:2025-08-29

摘要： 小肠细菌过度生长（small intestinal bacterial overgrowth，SIBO）是由小肠内细菌数量异常升高和（或）菌群改变引起，主要表现为腹痛、腹胀、便秘、腹泻等非特异性症状，病因复杂且与多种疾病有关，临床常见但尚未被充分认知。文章旨在阐述儿童 SIBO 的流行病学特征、发病机制、诊断方法及治疗策略，以期为临床实践提供参考。

关键词: 小肠细菌过度生长, 儿童, 近端小肠抽吸液培养, 利福昔明

Abstract: Small intestinal bacterial overgrowth （SIBO） is caused by an abnormally elevated number of bacteria and/or changes in the flora in the small intestine. It mainly presents with non-specific symptoms such as abdominal pain， bloating，constipation， and diarrhea. The etiology is complex and related to many diseases. It is common in clinical practice but has not been fully recognized. This article aims to review the epidemiological features， pathogenesis， diagnostic approaches， and treatment strategies of pediatric SIBO， with the goal of providing reference for clinical practice.

Key words: small intestinal bacterial overgrowth, child, culture of proximal small intestinal aspiration fluid, rifaximin