Abstract:

Palliative therapy in locally advanced and metastatic pancreatic cancer        SUN Bei，LIU Yuan-he. Department of Pancreatic and Biliary Surgery，the First Affiliated Hospital of Harbin Medical University，Harbin 150001，China
Corresponding author：SUN Bei，E-mail：sunbei70@tom.com
Abstract    The NCCN guideline of pancreatic cancer gives a definite suggestion of palliative treatment for locally advanced and metastatic pancreatic cancer. Endoscopic biliary stent is the first choice for biliary obstruction. Surgery is the best remedy for gastric outlet obstruction and the best treatment for tumor-associated pain is drugs. Surgery is not suitable for patients whose overall survival is less than 6 months. Biliary and gastric bypass, implantation of iodine-125 seed or neurolytic celiac plexus block are recommended for patients who are confirmed unresectable tumor intraoperatively. Satisfactory therapeutic effect could be achieved under the guidance of multidisciplinary team. Indeed, the treatment of palliative care will be improved with the development of technology obviously. 

Key words: advanced pancreatic cancer, palliative treatment

摘要：

美国国家综合癌症网络（NCCN）胰腺癌诊治指南对胰腺癌姑息治疗给予了明确指导，对于局部进展期及晚期胰腺癌的姑息治疗，解决梗阻性黄疸的首选方案是内镜下胆管支架治疗，解决消化道梗阻的最佳方案是手术干预治疗，而控制疼痛的首选治疗方案是药物治疗。对于生存期<6个月的病人，不建议行手术治疗，而对于在术中探查中发现肿瘤不能切除时，建议行胆肠吻合与胃肠吻合的双旁路手术及125I粒子植入或腹腔神经阻滞。胰腺癌的姑息治疗需要多学科综合治疗才能达到最理想的效果，相信随着技术的不断进展，胰腺癌的姑息治疗将会更加完善。

关键词: 进展期胰腺癌, 姑息治疗