Abstract:

Risk and prognostic factors of colorectal liver metastases          LIANG Li, LIU Tian-shu. Department of Medical Oncology，Zhongshan Hospital, Fudan University，Shanghai 200032, China
Corresponding author: LIU Tian-shu, E-mail: liu.tianshu@
zs-hospital.sh.cn
Abstract    Liver is the most common metastasis site of colorectal cancer, and the prognosis of colorectal liver metastases (CRLM)is poor. CRLM are divided into synchronous metastasis and metachronous metastasis. Single factor and multiple factor regression analyses show that the risk factors of CRLM include the depth of invasion, lymph node metastasis, tumor node, differentiation degree, tumor antigen and carbohydrate antigen. The factors influencing the prognosis of CRLM include the size and quantity of liver metastases, primary resection, surgical resection of liver metastases, systemic drug therapy and so on. Therefore, the surgical resection of liver metastases as well as drug therapy to get the opportunity of resection can maximize the survival of patients with CRLM. For a combination of a number of factors, the scoring system can better predict the prognosis of CRLM.

Key words: colorectal cancer, liver metastasis, risk factor, prognostic factor

摘要：

肝脏是结直肠癌最常见的远处转移器官，结直肠癌病人出现肝转移一般预后较差。结直肠癌肝转移分为同时性肝转移和异时性肝转移，对众多的临床以及病理学特征进行的单因素和多因素回归分析提示，影响结直肠癌发生肝转移的危险因素有：浸润深度、淋巴结转移、癌结节、分化程度、癌胚抗原和糖类抗原等。影响结直肠癌肝转移病人预后的因素有：肝转移灶大小及数目、肝外器官转移、原发灶手术切除、肝转移灶手术切除、全身药物治疗等。因此，手术切除肝转移灶、药物治疗获得手术切除机会等治疗模式能够最大程度地提高结直肠癌肝转移病人的存活率。由众多因素组合起来的评分系统，能够较好地预测结直肠癌肝转移病人的预后。

关键词: 结直肠癌, 肝转移, 危险因素, 预后因素