Abstract:

Objective:To observe the relationship between intestinal permeability and C Reactive Protein (CRP) in malnutrition gastric carcinoma patients. Methods:Thirty stomach cancer patients (fifteen malnutrition patients and fifteen normal nutrition patients) were enrolled in the study.Lactulose/mannitol test was performed on the day of hospitalization.The patients were retrospectively analyzed with automatic biochemistry analyzer for CRP. Results:L/M ratio of normal nutrition group was 0.049±0.010,and the malnutrition group was 0.161±0.141，respectively.Significant differences of L/M ratios were found between the two groups.The CRP changed significantly in high L/M ratio group (5.69 vs 17.40). Conclusion:The increase of intestinal permeability of malnutrition gastric carcinoma has great relation with inflammatory reaction.

Key words: Gastric carcinoma, Malnutrition, CRP, Intestinal permeability

摘要：

目的:前瞻性研究胃癌癌性营养不良病人肠黏膜通透性的变化及其与C反应蛋白(CRP)的关系。方法:选取2003年1月至2004年5月南京军区南京总医院普外科收治的进展期胃癌病人30例，营养不良者15例，营养正常者15例。口服含乳果糖10 g、甘露醇5 g 的测试液，收集服药后6 h全部尿液，用高效液相色谱法测定尿中乳果糖和甘露醇排泄率的比值（L/M）。同时测定血清中CRP浓度。结果:营养正常者L/M为（0.049±0.010），营养不良病人L/M为（0.161±0.141），营养不良病人尿中L/M明显增高(P<0.01)，L/M升高者血清CRP明显高于L/M正常者且差异具有显著性意义(P<0.05)。结论:胃癌营养不良病人肠黏膜通透性明显升高，该现象与炎性反应相关。

关键词: 胃癌, 营养不良, C反应蛋白, 肠黏膜屏障