Abstract:

Correlation between clinicopathological features and BRAFV600E gene mutation in papillary thyroid carcinoma        ZHU Chang-yu，GU Mei，DANG Shou-tao，et al.  Oncology Center，Beijing Tongren Hospital,Capital Medical University,Beijing 100730，China
Corresponding  author：GU Mei，E-mail：gumei64104@163.com
Abstract    Objective    To investigate the correlation between clinicopathological features and BRAFV600E gene mutation in papillary thyroid carcinoma（PTC）. Methods    The data of 290 cases of  PTC admitted from August 2016 to May 2018 in Beijing Tongren Hospital,Capital Medical University were analyzed retrospectively. All the cases of PTC were examined by BRAFV600E immunohistochemistry after operation. Mutation positive group included 192 cases. Mutation negative group included 59 cases  and partial mutation group included 39 cases. The cases of partial mutantion were excluded. The clinicopathological differences between the two groups were compared. Results    By statistical analysis，there was a statistical difference between two groups in the invasion of the capsule （P＜0.05）. In the two groups（microcarcinoma and non-microcarcinoma），there was the same result.There was no statistical difference in other indexes. Conclusion    In patients with PTC，BRAFV600E gene mutation is not associated with the clinicopathological features of the PTC. Patients with non-BRAFV600E gene mutations are more likely to invade the membranes of microcarcinomas and non-microcarcinomas.

Key words: papillary thyroid carcinoma, BRAFV600E gene mutation, clinicopathological features

摘要：

目的    探讨甲状腺乳头状癌临床病理学特征与BRAFV600E基因突变相关性。方法    回顾性分析2016年8月至2018年5月首都医科大学附属北京同仁医院290例甲状腺乳头状癌手术术后行BRAFV600E免疫组化检测的病人资料。其中突变192例，未突变59例，部分突变39例。剔除部分突变组行后续分析。比较两组病人的临床病理差异。结果    应用统计学分析，未突变组与突变组在被膜侵犯差异有统计学意义（P＜0.05）。将未突变组与突变组以微小癌及非微小癌为界分析，被膜侵犯在微小癌及非微小癌两组中差异均有统计学意义（P＜0.05）。其他指标差异无统计学意义。结论    在甲状腺乳头状癌病人中，BRAFV600E基因突变未见其与肿瘤的临床病理特征相关。非BRAFV600E基因突变的微小癌及非微小癌病人被膜侵犯可能性更大。

关键词: 甲状腺乳头状癌, BRAFV600E基因突变, 临床病理学特征