Abstract:

Multimodality management of rectal gastrointestinal stromal tumors        YE Ying-jiang,GAO Zhi-dong. Department of Gastrointestinal Surgery, Peking University People’s Hospital; Beijing Key Laboraory of Colorectal Cancer Diagnosis and Treatment Research,Beijing 100044, China
Corresponding author: YE Ying-jiang, E-mail:yeyingjiang@
pkuph.edu.cn
Abstract    Because of the special biological behavior and anatomical location, the diagnosis and treatment of gastrointestinal stromal tumor (GIST)  should be paid more attention. The combined use of endoscopic ultrasonography and MRI can improve the diagnostic accuracy of rectal GIST, and help to assess the range of surgical excision. The appearance of imatinib targeted treatment improved the therapeutic effect of rectal GIST and the complete resection rate of tumor. For the rectal GIST with a diameter of less than 5cm, local resection with imatinib can achieve a good therapeutic effect. At present, there is still a lack of standard of diagnosis and treatment for rectal GIST in the worldwide. More prospective multicenter studies are needed to further study and draw conclusions in the future.

Key words: gastrointestinal stromal tumor, rectum, target therapy

摘要：

直肠胃肠间质瘤（GIST）生物学行为和解剖部位特殊，其诊治应受到重视。通过超声内镜和MRI联合应用可以提高直肠GIST的诊断准确性，并且有助于评估手术切除范围。伊马替尼靶向治疗的出现改善了直肠GIST的治疗效果，提高了肿瘤完整切除率。对于直径＜5 cm的直肠GIST采用局部切除联合伊马替尼治疗可以达到较好的治疗效果。目前，国内外尚缺少直肠GIST的诊疗规范，未来还需要更多的前瞻性多中心研究进一步探讨并得出结论。

关键词: 胃肠间质瘤, 直肠, 靶向治疗