Abstract:

The standardized nutrition support therapy for advanced gastric cancer        ZHANG Wei，ZHU Wei-ming. Department of General Surgery, General Hospital of Nanjing Military Command of the Chinese People’s Liberation Army, Nanjing 210002，China
Corresponding author：ZHU Wei-ming，E-mail：juwiming@126.com
Abstract    The rate of the malnutrition is very high in the patients with advanced gastric cancer (GC) who have short survival time and poor prognosis. For lack of the basic necessitated nutritional conditions，malnutrition decreases the tolerance and response of the patients for chemotherapy，and thereby having impact on the effective treatment which leads to the failure of chemotherapy and further makes the patients lose the operative opportunity. Under the combined influence of chemotherapy and operation，ignorance of the malnutrition would increase significantly the rate of postoperative complications. Therefore，during the multidisciplinary treatment，the patients with malnutrition had better receive the active nutritional support and intervention as soon as necessary. It is unnecessary to worry about the theoretical tumor growth of nutrition support. Due to the failure of chemotherapy，the patients would be final stage with the feature of poor prognosis，and therefore the influence on the prognosis of the nutrition support is very little，and even neglectable. Owing to the successful chemotherapy，the patients are hopeful to receive radical operation that can increase the survival time significantly. So，it is prominent to display the synergetic anticancer effect of the nutrition support，such as the increasing success rate of the chemotherapy and the significant improvement of the prognosis.

Key words: advanced gastric cancer, nutritional support, multidisciplinary treatment, survival time

摘要：

晚期胃癌病人生存期短、预后差，且营养不良的发生率很高。营养不良的发生降低了病人对化疗的耐受性和反应性，不能为化疗提供必备的营养基础条件，无法保障化疗的有效实施，可导致化疗失败，失去手术的机会。在化疗和手术的双重打击下，如不纠正营养不良则将增加手术并发症的发生风险。因此，在综合治疗过程中，应采取积极的营养支持治疗，及早进行营养干预。营养支持无需顾虑其理论上的促肿瘤生长作用。化疗失败则进入终末期，对原本预后极差的病人，营养支持对预后的影响非常小，可以忽略。而化疗成功则有望行根治性手术，可能明显延长生存期，这凸显了营养支持治疗提高化疗成功率、明显改善预后的协同抗癌效果。

关键词: 晚期胃癌, 营养支持, 综合治疗, 生存期