Abstract:

Diagnostic value of frozen section for thyroid carcinoma variants        PING Bo. Department of Pathology，Fudan University Shanghai Cancer Center；Department of Oncology，Shanghai Medical College，Fudan University，Shanghai 200032，China
Abstract    As relatively uncommon or even rare diseases, variants of thyroid carcinoma have different pathological features from those of the conventional types. Besides, a couple of the variants are more invasive and show comparatively worse prognosis, thus becoming high-risk histology types. Identifying the variants pre- or intraoperatively would therefore benefit surgical planing.  Although the accuracy of type-specific diagnosis is more often guaranteed by post-operative paraffin section and /or immunohistochemistry rather than by frozen section (FS) , the latter remains an important role in improving the diagnosis of those thyroid carcinoma variants with indeterminate or misleading preoperative judgement.

Key words: thyroid carcinoma, conventional type, variants, frozen section

摘要：

甲状腺癌亚型相对少见，甚至罕见，不仅在多种病理学特征方面不同于传统型，而且少数甲状腺癌亚型相较传统型更具侵袭性且预后相对不良，属高危组织学类型，如能于术前或术中被准确识别，将有助于手术方式选择。虽然术中快速冰冻病理切片检查（frozen section，FS）对于亚型之类型诊断的准确性远未达到理想，常需等待术后石蜡切片和（或）免疫组化检查确诊，但FS的一项重要价值在于依然可能帮助术前不确定为恶性或误诊的亚型病例进一步明确诊断。

关键词: 甲状腺癌, 传统型, 亚型, 冰冻切片