Abstract:

Confusion in the diagnosis and treatment of gallbladder cancer and its future breakthrough        BIE Ping, CHEN Zhi-yu. Research Institute of Hepatobiliary Surgery of PLA, the First Affiliated Hospital of the Third Military Medical University, Chongqing 400038, China
Corresponding author: BIE Ping, E-mail:bieping@medmail.com.cn
Abstract    Gallbladder cancer is the common malignant tumor of biliary duct system with high malignancy and poor prognosis. Its 5-year survivor rate remains low in the past 20 years. Comprehensive treatment based on surgery remains the treatment principle for gallbladder cancer. Laparoscopic surgery remains controversy for the treatment of gallbladder cancer with at least T2 stage. The tumor extension, invasion of lymph node and vascular determine the range of gallbladder cancer expand resection. Searching specific gene targets will improve the long-term prognosis of gallbladder cancer in current precision medicine era.

Key words: gallbladder cancer, precision medicine, targeted therapy

摘要：

胆囊癌是胆道系统常见的恶性肿瘤，其发病隐匿，发现时多已处于进展期，恶性程度高，远期疗效差，5年存活率在近20年无明显提高。以手术为主的综合治疗仍然是胆囊癌的治疗原则。T2期以上胆囊癌行腹腔镜下根治术仍存较大争议。胆囊癌侵犯的范围及淋巴结、血管受累程度，决定胆囊癌扩大根治术的切除范围。精准医疗时代寻找胆囊癌的特定靶点将有助于提高胆囊癌的远期疗效。

关键词: 胆囊癌, 精准医学, 靶向治疗