Abstract:

Establishment and value of three-dimensional visualization diagnosis platform in the treatment of hepatolithiasis        FANG Chi-hua, FANG Zhao-shan, CAI Wei, et al. The First Department of Hapatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou510282,China
Corresponding author:FANG Chi-hua,E-mail: fangch_dr@126.com
Abstract    Objective    To study the establishment and value of three-dimensional visualization diagnosis platform in the treatment of hepatolithiasis. Methods    The clinical data of 112 consecutive patients with hepatolithiasis between January 2008 and April 2015 in the First Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University were analyzed. (1) In order to acquire submillimeter CT data, each patient underwent the spiral CT epigastric enhancement scanning. Medical image three-dimensional visualization system (MI-3DVS) was used to establish three-dimensional visualization image model. (2) The three-dimensional visualization analysis covered the vascular classification, the classification of clinical diagnosis, liver segments, virtual hepatectomy and liver volume calculation with three-dimensional visualization technology. (3) Preoperative evaluation and surgical planning were performed to select a reasonable plan. (4) The 3D printing of liver might be performed when necessary, which help to perform the precise surgery. (5) Therapeutic effect was evaluated. Results    All the patients had a real reconstruction of three-dimensional visualization image model based on CT images. The position and distribution of calculus, location and degree of biliary stricture, vascular anatomic relationships were shown in the three-dimensional visualization image model clearly. The category of hepatic artery, hepatic vein and portal vein were made. The three-dimensional visualization diagnostic classification of hepatolithiasis and liver segments was also performed. The relationships between lesions and vasculature were shown in the 3D printing model of liver. The three-dimensional visualization preoperative evaluation and 3D printing model were in tune with actual operation. The stone residue rate, incidence rate of complications and calculus recurrence rate was less than 3.0%, 5.6% and 2.4% respectively. Conclusion    The establishment of three-dimensional visualization diagnosis platform for hepatolithiasis could help to improve the clearance of calculus and decrease postoperative complications. It could provide safe, precise, minimally invasive and efficient therapeutic measures for hepatolithiasis and has a good clinical prospect.

Key words: hepatolithiasis, 3D printing, three-dimensional visualization

摘要：

目的    研究肝胆管结石三维可视化诊治平台的构建及临床应用价值。方法    收集南方医科大学珠江医院肝胆一科2008年1月至2015年4月符合纳入标准的112例肝胆管结石病人临床资料。（1）对肝胆管结石病人进行上腹部增强CT扫描，获取亚毫米CT数据，采用腹部医学图像三维可视化系统（MI-3DVS）构建三维可视化图像模型。（2）然后进行三维可视化分析，包括三维可视化脉管分型、三维可视化肝胆管结石临床诊断分型、三维可视化肝分段、虚拟肝切除术和体积计算。（3）术前评估、手术规划，制定合理的手术方式。（4）根据需要进行三维可视化肝脏3D打印，用于指导精准手术治疗。（5）疗效评估。结果    112例病人均构建了忠实于CT图像数据的三维可视化图像模型，能清晰显示结石的部位、分布，胆管狭窄的部位、程度，以及脉管的空间解剖关系；进行了肝动脉、肝静脉、门静脉的三维可视化分型、三维可视化肝胆管结石临床诊断分型、三维可视化肝分段。三维可视化肝脏3D打印模型可以从全方位展示病变与血管相互关系；三维可视化术前规划、三维可视化肝脏3D打印模型与实际手术一致。总手术残石率<3%、并发症发生率<5.6%、术后结石复发率<2.4%。结论    肝胆管结石三维可视化诊治平台的构建，有助于提高结石清除率和降低术后并发症发生率。为肝胆管结石治疗提供一个安全、精准、微创、高效的治疗措施，具有良好的临床应用前景。

关键词: 肝胆管结石, 3D打印, 三维可视化