Abstract:

Diagnosis and management of intrahepatic cholangiocarcinoma        CHEN Ya-jin, SHANG Chang-zhen. Department of Hepatobiliary Surgery, Sun Yat-sen memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
Corresponding author: CHEN Ya-jin，E-mail：cyj0509@126.com
Abstract    The worldwide incidence of intrahepatic cholangiocarcinoma (ICC) keeps increasing in recent years. The biological characteristics of ICC are significantly different from that of hepatocellular carcinoma (HCC) and extrahepatic cholangiocarcinoma, and often remains asymptomatic until an advanced stage. Thus, regular screening of the population with high risk factors is essential for early diagnosis and timely treatment of ICC. The current ICC staging systems provide helpful clinical references for the evaluation of prognosis, but there are still some argues about which impact factors should be included in the staging system. Therefore, large-scale prospective studies should be carried out so as to amend the current staging system. Multidisciplinary treatments mainly with surgical resection are an optimal treatment method for ICC. Radical resection combined with lymphadenectomy may improve the prognosis of ICC patients. For those who have losen surgical treatment chance or suffered recurrent ICC, non-surgical treatment methods may also prolong the survival time of ICC patients.

Key words: intrahepatic cholangiocarcinoma, radical resection, multidisciplinary treatment; , evidence-based medicine

摘要：

肝内胆管细胞癌（intrahepatic cholangiocarcinoma， ICC）的生物学特性与肝细胞癌和肝外胆管癌存在显著差异，早期缺乏明显临床表现。因此，对合并高危因素的人群进行定期筛查，有助于ICC的早期诊断和及时治疗。现有ICC分期系统为预后评估提供了临床依据，但是在影响病人预后因素方面尚存在分歧，有待大规模前瞻性研究提供循证医学证据，进一步修订、完善分期系统。以手术为主的综合治疗是ICC的主流治疗模式，根治性切除和淋巴结清扫有助于提高疗效、改善病人预后，非手术治疗方法的不断进展可使无法手术或术后复发ICC病人临床获益。

关键词: 肝内胆管细胞癌, 根治性切除, 综合治疗, 循证医学