Abstract: Study on continuous improvement of prevention program of perioperative venous thromboembolism for inguinal hernia (CHAT-3)        LIU Yu-chen*, ZHANG Hong-ming☆, ZHANG Zi-chao, et al. *Beijing Chaoyang Hospital, Capital Medical University，Beijing100020，China; ☆The Number One Hospital of Zhangjiakou， Zhangjiakou075041，China
Corresponding authors：LI Hang-yu，E-mail：li_hangyu@126.com；WANG Ming-gang，E-mail：wmgonly@126.com
LIU Yu-chen and ZHANG Hong-ming are the first authors who contributed equally to the article.
Abstract    Objective    To verify the safety and effectiveness of VTE specialist assessment for prevention in patients undergoing inguinal hernia surgery. Methods    Data of patients undergoing inguinal hernia surgery from 9 different hospitals from June 2020 to June 2021 were collected，and they were randomly divided into observation group and control group.The observation group was evaluated with the specialized version of the prevention plan，and the control group was assessed with the current prevention plan of each center.General information，hernia type，operation time，operation method，preoperative laboratory examination and lower extremity vascular ultrasound were recorded.The changes of laboratory examinations in the two groups were recorded during the 4-week follow-up.The assessment rate and prevention rate were compared between the two groups. Results    There was no significant difference in general data between the two groups（P＞0.05），and no significant difference in preoperative laboratory examinations between the two groups（P＞0.05）.In the experimental group，27 cases（5.23%）with D-DImer abnormality were screened by screening program before surgery，8 cases（1.55%）were VTE positive confirmed by ultrasound，132 cases（25.58%）were prophylactic with low molecular weight heparin and 4 cases（0.77%）were oral anticoagulant after evaluation of preliminary screening program.In the control group，36 cases（5.95%）with D-Dimer abnormality were screened by preoperative screening program，13 cases（2.15%）with VTE positive confirmed by ultrasound，23 cases（3.80%）with low molecular weight heparin for prophylaxis and 14 cases（2.31%）with oral anticoagulant were evaluated according to the existing evaluation program of each center.One week after surgery，the difference in D-Dimer and PLT values between the two groups was statistically significant（P＜0.05），and the experimental group was significantly lower than the control group.Four weeks after surgery，there were no significant differences in d-Dimer，WBC，PLT，ALT and AST between the two groups（P＞0.05）. Conclusion    The specialized evaluation and prevention scheme of VTE in inguinal hernia surgery is safe and effective.Compared with caprini evaluation system，it is more precise and can ensure the needs of patients' perioperative VTE management.

Key words: inguinal hernia, venous thromboembolism, assessment, prevention, management 

摘要： 目的    验证腹股沟疝手术病人静脉血栓栓塞症（VTE）专科版评估预防方案的安全性和有效性。方法    收集2020-06-01—2021-06-30来自国内9家医院的腹股沟疝手术1234例病人资料，随机分为试验组和对照组，试验组采用专科版评估预防方案，对照组采用现行评估预防方案。记录病人的一般资料、疝类型、手术时间、手术方式、术前实验室检查、下肢血管超声等。术后随访4周，分别记录两组病人的实验室检查结果。对两组病人的评估率和预防率进行比较。结果    两组病人的一般资料差异无统计学意义（P＞0.05），两组病人术前实验室检查差异无统计学意义（P＞0.05）。试验组术前通过筛查方案筛查D-二聚体（D-Dimer）异常者27例（5.23%），经超声证实VTE阳性病例8例（1.55%），评估后使用低分子肝素预防132例（25.58%），使用口服抗凝药4例（0.77%）；对照组术前通过筛查方案筛查D-Dimer异常者36例（5.95%），经超声证实VTE阳性病例13例（2.15%），根据现有评估方案评估后使用低分子肝素预防23例（3.80%），口服抗凝药14例（2.31%）。术后1周随访，两组病人的D-Dimer和PLT数值差异具有统计学意义（P＜0.05），试验组显著低于对照组。术后4周随访，两组病人的D-Dimer、白细胞（WBC）、血小板（PLT）、丙氨酸转氨酶（ALT）、天冬氨酸转移酶（AST）数值两组差异无明显统计学意义（P＞0.05）。结论    腹股沟疝手术VTE专科版评估预防方案是安全有效的，相比于Caprini评估体系更为精准，能够保证病人围手术期VTE管理需求。

关键词: 腹股沟疝, 静脉血栓栓塞症, 评估, 预防, 管理