Abstract: Conversion surgical resection of unresectable advanced hepatocellular carcinoma        XIAO Zhi-yu, CHEN Ya-jin. Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China 
Corresponding author：CHEN Ya-jin，E-mail: cyj0509@126.com
Abstract    Most hepatocellular carcinoma（HCC）patients have insidient onset，with no obvious early symptoms but rapid progress，and are already in the middle and advanced stages when they are diagnosed, and have a poor prognosis. Conversion treatment could downstaged the advanced HCC successfully into resectable HCC and achieve R0 resection. The detailed and comprehensive assessment of tumor burden, liver function and functions of other organs, could provide the basis for the preoperative decision of safe hepatectomy after conversion therapy. It is recommended that the multidisciplinary team should evaluate the treatment effect regularly, and make a timely surgical resection plan during conversion therapy.

Key words: hepatocellular carcinoma, conversion treatment, downstaging, hepatectomy

摘要： 多数肝癌起病隐匿，早期症状不明显，就诊时往往已属中晚期，预后不佳。转化治疗可使不可切除晚期肝癌病人获得手术治疗机会，并达到R0切除。在转化治疗后，对病人肿瘤、肝脏及其他器官细致全面的评估，将为安全肝切除的术前决策提供依据。转化治疗期间建议采用多学科综合治疗协作组模式定期评估转化治疗效果，并及时制定手术切除方案。

关键词: 肝细胞癌, 转化治疗, 降期, 肝切除术