Abstract: Current state and thinking of liver cancer conversion therapy        CHEN Ya-jin. Department of Hepatobiliary Surgery，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510120，China
Abstract    Surgical resection is still being considered as the most effective approach for the hepatocellular carcinoma（HCC） in order to obtain the radical treatment and long-term survival. Therefore，it is important to strive radical surgery for new patients diagnosed with intermediate-stage or advanced HCC，which accounts for 70% to 80% out-patients，to offer them improved prognosis. Conversion therapy has well developed nowadays due to the escalated application of downstaging therapy. Recently，the combination of systemic and regional treatments，as well as multi-mode sequential therapy showed a promising conversion rate. However，due to the limited development time，many problems still need to be further explored，including the optimization of conversion therapy，effect evaluation，timing of surgery，safety management，hyperprogressive disease（HPD）and prevention of recurrence, etc. According to the previous clinical experience and research data，the author assumes that HCC conversion therapy should include multi-dimensional，multi-mode sequential，multi-disciplinary principles，and the "Triple multi-" concept should be taken as a strategy running through the whole process of HCC patients’management，in order to achieve highly individualized and precise treatment.

Key words: hepatocellular carcinoma, conversion therapy, downstaging treatment, systemic treatment, multiple-discipline team

摘要： 手术切除仍是实现肝细胞癌（HCC）根治和获得长期生存的最重要手段。由于HCC病人初诊为中、晚期比例高达70%～80%，因此，为其争取根治性手术机会对提升HCC总体预后意义重大。源于降期治疗的升级，转化治疗应运而生。系统与局部治疗的多维度联合、多模式序贯显示出了可喜的转化成功率。然而，由于发展时间尚短，诸多问题有待继续深入探索，包括转化治疗方案的优化、效果评价、手术时机把握、安全性管理、超进展（HPD）和术后复发防治等。HCC转化治疗应以全局观和整体思维将多维度联合、多模式序贯、多学科高度一体化的“三多”理念高度融入并贯穿于病人疾病全程管理的系统化战略，在该原则指导下力求实现高度个体化、精准化治疗。

关键词: 肝细胞癌, 转化治疗, 降期治疗, 系统治疗, 多学科综合治疗协作组