Abstract: Local regional therapies for intrahepatic cholangiocarcinoma        CHEN Min-shan，FU Yi-zhen. Department of Liver Surgery，Sun Yat-sen University Cancer Center，Guangzhou 510060，China
Corresponding author：CHEN Min-shan，E-mail：chenmsh@
sysucc.org.cn
Abstract    Intrahepatic cholangiocarcinoma（ICC）is a kind of rare，highly aggressive primary liver cancer. There has been limited options for the treatment of ICC with surgical resection the only potentially curative choice. Local regional therapies（LRTs）consist of ablation，intra-arterial therapies（IATs）and radiotherapy. LRTs could be applied to the treatment of each stage of ICC. For early stage ICC patients who were not amenable for surgery，ablation might bring out comparable outcomes to surgery； for local advanced ICCs，LRTs reduced the tumor burden as well as provide symptomatic relief and had a positive effect on survival；and for patients underwent resection，adjuvant radiotherapy and transarterial chemoembolization may reduce the risk of tumor recurrence. Hence，the authors suggested that LRTs played essential roles in the multidisciplinary approaches to ICC.

Key words: intrahepatic cholangiocarcinoma, local regional therapy, ablation, intra-arterial therapy, radiotherapy

摘要：

肝内胆管癌（intrahepatic cholangiocarcinoma，ICC）是一种较为少见、高度侵袭性的原发肝脏恶性肿瘤。ICC的治疗手段较为有限，手术治疗是惟一的根治性手段，局部治疗近年技术有较多大的进展，主要包括消融治疗、介入治疗和放射治疗。局部治疗可贯穿于ICC治疗的整个过程之中。对于不适合手术的早期ICC病人，局部治疗有达到治愈的可能；对于中晚期ICC病人，局部治疗可以降低肿瘤负荷、缓解症状、延长生存，甚至有机会通过局部治疗获得手术机会；而辅助介入治疗或者放射治疗也可以降低根治性术后病人复发的风险。由此可见，局部治疗是ICC多学科综合治疗的重要组成部分，可使病人获益。

关键词: 肝内胆管癌, 局部治疗, 消融治疗, 介入治疗, 放射治疗