Abstract:

Clinicopathologic analysis of 38 male breast cancers        LI Hai-li, ZHOU Jue, JIA Xiu-peng, et al. Clinical Pathology Diagnostic Center of Ningbo, Ningbo 315000, China
Corresponding author: LI Hai-li, E-mail:hailey2012@foxmail.com
Abstract    Objective    To analyze the clinicopathologic characteristics and molecular subtype in male breast cancer (MBC). Methods    The clinical features, histological features and molecular subtype of 38 cases of male breast cancers admitted from January 2013 to March 2019 in Clinical Pathology Diagnostic Center of Ningbo were analyzed retrospectively. Results    Thirty-eight patients were diagnosed with MBC, accounting for 0.83% of all the breast cancer in the same term. The median age was 68.5 (range from 24 to 88). Tumor were located in left side in 20 cases, right side in 18 cases. Twenty-nine cases were diagnosed as invasive ductal carcinoma, two cases of secretory breast cancer, one case of invasive solid papillary carcinoma, two cases of intraductal papillary carcinoma with microinvasive, and four cases of encapsulated papillary carcinoma (two of them with microinvasive). Sixteen patients had lymphatic metastasis when the tumor was diagnosed. Imunohistochemically, ER was positive in 36 cases, while PR was positive in 35 cases. Eighteen cases were Luminal A type, while sixteen were Luminal B type and two cases were basal-like subtype. Conclusion    MBC is a rare malignant neoplasm, and most patients are diagnosed older and at advanced clinical stage, what is more, there is more possibility of second non-breast primary cancer. All suggesting that early diagnosis, treatment and more intensive surveillance are important. MBC needs further study.

Key words: male breast cancer, clinicopathologic feature, the second primary cancer

摘要：

目的    分析男性乳腺癌的临床病理及分子分型特点。方法    回顾分析宁波市临床病理诊断中心2013年1月至2019年3月38例男性乳腺癌病例的临床病理和分子分型资料。结果    38例男性乳腺癌病人，占同期乳腺癌病人0.83%，中位年龄68.5（24～88）岁，病灶位于左侧20例，位于右侧18例。其中29例为浸润性导管癌，2例为分泌性癌，1例为实性乳头状癌伴微浸润， 2例为导管内乳头状癌伴微浸润，4例为包裹性乳头状癌（其中2例伴微浸润）。浸润性导管癌组织学分级Ⅰ级2例，Ⅱ级20例，Ⅲ级7例。16例伴淋巴结转移。免疫组化染色：36例ER 阳性，35例PR阳性。分子分型Luminal A型18例，Luminal B型16例，基底细胞型2例。结论    男性乳腺癌少见，发病年龄较晚，临床分期较高，预后较差，且发生第2种原发性癌的可能性增加，加强对其认识，争取早期诊断、治疗及监测非常重要。男性乳腺癌仍须扩大样本量进一步研究。

关键词: 男性乳腺癌, 临床病理特征, 第二原发性癌