Abstract:

Difficulties and countermeasures of integrated therapy for advanced pancreatic cancer        MIAO Yi. Pancreas Center，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China
Abstract    Locally advanced pancreatic cancer leaves us endless confusion and reflection in clinical definition, resectability, neoadjuvant chemoradiotherapy, and surgical strategies. The biological behavior of the tumor determines the prognosis ultimately. The multidisciplinary comprehensive treatment of locally advanced pancreatic cancer, based on surgical resection, is changing from “morphological model” to “biological model”. The prediction of biological behavior of pancreatic cancer and the screening of subclinical micrometastasis play an important role in the rational treatment of patients.

Key words: pancreatic carcinoma, locally advanced stage, comprehensive therapy

摘要：

局部进展期胰腺癌在临床界定、可切除性判断、新辅助治疗以及手术策略方面留给我们无尽的困惑和思考。肿瘤的生物学行为决定病人最终的预后。局部进展期胰腺癌以手术切除为主的多学科综合治疗正在从“形态学模式”向“生物学模式”转变。胰腺癌生物学行为的预判和对亚临床微小转移的甄别，对选择使病人获益的合理治疗方法具有重要的意义。

关键词: 胰腺癌, 局部进展期, 综合治疗