胃肠间质瘤（gastrointestinal stromal tumor，GIST）是消化道最常见的间叶源性肿瘤。腹膜后GIST的生长类型少见，没有固定术式，应该根据GIST手术原则，在充分准备的基础上，对应具体病例制定手术方案。结合靶向药物的术前辅助治疗，认真评估手术风险和收益，对提高手术切除率，保存脏器功能，减少手术并发症至关重要。

Surgical management of retroperitoneal gastrointestinal stromal tumor        HE Yu-long, ZHANG Xin-hua. Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
Corresponding author: HE Yu-long, E-mail: YLH@medmail.com.cn
Abstract    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of gastrointestinal tract. Retroperitoneal GIST is a special growth pattern, which should be resected on a case-to-case basis and be consistent with the principal of surgery in GIST. Combining preoperative imatinib adjuvant therapy in selective patients, seriously evaluating the risk and benefit of surgery are crucial in bringing higher resection rate, better perseveration of organ function and lower morbidity and mortality rates of surgery.