随着临床综合治疗手段和方法的不断进步，对腹膜后肿瘤，尤其是复杂性腹膜后肿瘤，术前即获取穿刺组织，进行常规病理诊断，甚至分子病理学诊断的需求越来越高。在穿刺组织上，通过常规病理诊断、免疫组织化学、荧光原位杂交以及基于PCR的分子病理技术，获得肿瘤类型、分子靶点以及药物敏感性化疗靶标等信息，为腹膜后肿瘤个体化治疗提供参考，使病人更好地从综合治疗中获益，具有重要临床意义。

Preoperative pathologic diagnosis methods and important significance for complex retroperitoneal tumor        HOU Ying-yong, JIANG Dong-xian. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Corresponding author: HOU Ying-yong, E-mail: houyingyong@hotmail.com
Abstract    For retroperitoneal tumors, especially complex retroperitoneal tumors, preoperative pathologic and molecular diagnoses are increasingly getting high demand with the means and methods of clinical comprehensive treatment progresses. The tumor type, molecular targets and drug sensitivity information are available through puncture-based tissues by routine histopathology, immunohistochemistry, fluorescence in situ hybridization and PCR-based molecular pathological technology. Patients will benefit from individualized treatment after referring to the information. Therefore, preoperative diagnosis has important clinical significance for complex retroperitoneal tumor.