目的 研究乳腺原发性非霍奇金淋巴瘤的临床病理特点与预后。 方法 对中国医学科学院肿瘤医院1999-2008年23例乳腺原发性非霍奇金淋巴瘤的临床资料进行分析，复习病史、治疗经过和随访资料。 结果 弥漫大B细胞淋巴瘤11例，黏膜相关边缘带B细胞淋巴瘤伴大细胞转化5例，小淋巴细胞淋巴瘤5例，自然杀伤细胞（NK）/T细胞淋巴瘤1例，Burkitt淋巴瘤1例。肿物切除20例，乳腺改良根治手术3例。9例手术后化疗，6例手术后化疗和放疗，1例化疗缓解后造血干细胞移植。21例随访3~62个月，17例存活，4例死亡，2例失访。12例有复发和进展。 结论 乳腺原发性非霍奇金淋巴瘤最常见的组织学类型是弥漫大B细胞淋巴瘤。肿瘤切除术加放疗和（或）化疗是主要治疗方法，预后差，易于复发。

Clinicopathologic characteristics and prognosis analysis of primary breast non-Hodgkin’s lymphoma XUAN Li-xue*, SHI Su-sheng, FENG Min, et al. *Center of Breast Disease, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing100021, China Corresponding author: SHI Su-sheng, E-mail: shishusheng@sina.com Abstract Objective To investigate the clinicopathologic characteristics and prognosis of primary non-Hodgkin’s lymphoma (NHL) in breast. Methods The clinical data of 23 cases of primary non-Hodgkin’s lymphoma in breast admitted from 1999 to 2008 at Cancer Hospital of Chinese Academy of Medical Science were analyzed. And the clinical histories, treatment course and follow-up information were reviewed. Results Diffuse large-B cell lymphoma (DLBCL) presented in 11 cases. Marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (MALT-MZL) with large cell transform presented in 5 cases. Small lymphocytic lymphoma presented in 5 cases. NK/T lymphocytic lymphoma presented in 1 case. Burkitt lymphoma presented in 1 case. Twenty cases received lumpectomy, and 3 received modified mastectomy. Nine cases received chemotherapy postoperatively including 1 case received hematopoietic stem cell transplantation after chemotherapy. Six cases received both chemotherapy and radiotherapy. The follow-up time of 21 cases ranged from 3 to 62 months. While 2 cases were lost of follow-up. In the 21 cases, 17 cases were alive, while 4 cases had died. Recurrence or progress presented in 12 cases. Conclusion Diffuse large-B cell lymphoma is the most common primary non-Hodgkin’s lymphoma in breast. Resection plus chemotherapy and (or) radiotherapy are the main treatments. The prognosis is poor and recurrence and progress often occurred.