目的:探讨胃肠间质瘤联合脏器切除的指征及方法。方法:回顾性分析1994-2005年复旦大学附属肿瘤医院收治的22例胃肠间质瘤行联合脏器切除的病例资料。结果:联合脾切除８例，结肠切除６例，肾脏切除５例，肝部分切除１例，十二指肠切除１例，卵巢切除１例，胰体尾切除３例，肾上腺切除１例，两个脏器切除３例，三个脏器切除２例，5例胃间质瘤及２例小肠间质瘤淋巴结清扫术后，未证实淋巴结转移，病理检查提示肿瘤累及肾、脾、胰、各２例，肠系膜与大网膜各１例，全组无死亡病例。随访14例，９例存活，５例因肿瘤复发转移死亡。结论:胃肠间质瘤如侵犯周围脏器，联合脏器切除对病人可能有益，掌握手术指征也很重要。与靶向药物结合外科治疗胃肠间质瘤更为适合。

Objective:To investigate the indication and method of gastrointestinal stromal tumor (GIST) complicated with multivisceral resection. Methods:The clinical data of 22 cases of GIST complicated with multivisceral resection between 1994 and 2005 in the Cancer Hospital of Fudan University were analyzed retrospectively. Results:The types of multivisceral operation included splenectomy (n=8),coloectomy (n=6),nepherectomy (n=5),partial hepatectomy (n=1),duodenectomy (n=1),oophorectomy (n=1),pancreatectomy (n=3),and adrenalectomy (n=1).Three cases were performed two adjacent organs resection, and 2 cases were performed 3 adjacent organs resection. None of lymph node metastasis was found in 7 cases with lymph node dissection with gastric stromal tumor (n=5) and small intestinal stromal tumor (n=2).The involved organs comfirmed by the pathology diagnosis included kidney (n=2),spleen (n=2),pancreas (n=2),mesentery (n=1) and omentum (n=1).There was no postoperative mortality in the series.Among followed up patients, 9 were survival and 5 cases were died from the tumor recurrence or metastasis. Conclusion:For the cases of GIST invading the adjacent organs,multivisceral resection could be benefit.Meanwhile,the operation indications are very important.Target drug combined with surgery may be a better method for the treatment of GIST.