胃肠间质瘤（GIST）治疗方式首选手术切除。腹腔镜联合内镜手术（LECS）融合了内镜与腹腔镜优势，在安全有效前提下减少并发症、加速康复并改善生活质量。其为胃GIST提供精准诊断及多样化保功能选择，经典LECS、内翻LECS、腹腔镜辅助内镜全层切除术（LAEFR）及非暴露式LECS各有适应证，需依肿瘤大小、位置及风险分层个体化选用。LECS技术要求高、学习曲线长，宜在设备完善的大型中心开展。其可联合吲哚菁绿荧光导航、前哨淋巴结活检及机器人系统，提升肿瘤定位、切缘判断及血供评估精度。目前，LECS主要用于胃GIST，并可拓展至十二指肠、小肠及结直肠。临床中心应加强内镜技能培训，建立准入标准。未来仍需更多前瞻性多中心研究及长期随访，提供高级别循证证据以验证远期疗效。

Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor of the digestive tract, and surgical resection is the preferred treatment method. Laparoscopic and endoscopic cooperative surgery (LECS), combine the respective advantages of laparoscopy and endoscopy to achieve precise localization, complete resection, functional preservation, and minimally invasive treatment of GIST. In recent years, LECS has developed into various surgical techniques with different indications and advantages in clinical application. This article systematically summarizes the main surgical techniques, clinical application selection strategies, and research progress of LECS for the treatment of GIST. Combined with relevant guidelines and clinical practice, it also summarizes the technical points and difficulties in the implementation of LECS, aiming to further promote LECS and provide references for clinical practice.