目的 探讨非暴露式内镜下胃壁内翻切除（NEWS）联合腹腔镜前哨淋巴结导航手术（LSNNS）治疗早期胃癌的临床安全性与短期有效性。方法 回顾性分析2025年1月至2026年5月北京大学人民医院胃肠外科收治的行NEWS联合LSNNS治疗的7例早期胃癌病人的临床病理资料，收集围手术期随访数据，评估临床安全性、根治效果及应用价值。结果 7例病人的病灶中位长径为2.0（1.5~3.0）cm。2例合并溃疡。病理检查示，以印戒细胞癌及低分化腺癌为主，3例病灶浸润至黏膜下层。所有病人均顺利完成NEWS联合LSNNS，无中转开放手术病例，平均手术时间为（268.9±47.7）min，术中出血量为15~50（24.3±12.4） mL。所有病人手术切缘均为阴性，前哨淋巴结清扫数目为4~9枚，术后病理检查示淋巴结转移阴性。围手术期无出血、穿孔、腹腔感染等严重并发症，病人术后疼痛及炎性应激反应较轻，仅2例出现短暂轻度胃排空障碍，术后中位住院时间为5（5~7）d。结论 NEWS联合LSNNS是一种安全、可行、微创的新型手术方式，可实现高危型早期胃癌病灶的完整全层切除与个体化淋巴结清扫，围手术期安全性可靠，同时可保留胃部解剖结构与生理功能。

Objective To investigate the clinical safety and short-term efficacy of non-exposed endoscopic wall-inversion surgery (NEWS) combined with laparoscopic sentinel node navigation surgery (LSNNS) in the treatment of early gastric cancer. Methods A total of 7 patients with early gastric cancer who underwent NEWS combined with LSNNS at the Department of Gastrointestinal Surgery, Peking University People’s Hospital, from January 2025 to May 2026 were retrospectively enrolled. The clinicopathological data and perioperative follow-up data of the patients were collected and sorted to evaluate the clinical safety, radical resection efficacy, and application value of this surgical procedure. Results The median maximum lesion diameter of 7 patients was 2.0 (1.5-3.0) cm, and 2 cases were complicated with ulcers. The pathological types were mainly signet ring cell carcinoma and poorly differentiated adenocarcinoma, and tumor invasion into the submucosa was observed in 3 cases. All patients successfully completed NEWS combined with LSNNS without conversion to open surgery. The average operative time was (268.9±47.7) minutes, and the intraoperative blood loss ranged from 15 to 50 mL. Negative surgical margins were achieved in all patients, with 4 to 9 sentinel lymph nodes dissected per case, and postoperative pathology confirmed no lymph node metastasis. No severe complications such as hemorrhage, perforation or abdominal infection occurred during the perioperative period. Patients presented with mild postoperative pain and slight inflammatory stress response, and only 2 cases developed transient mild gastric emptying disorder. The median postoperative hospital stay was 5 (5-7) days. Conclusion NEWS combined with LSNNS is a safe, feasible and minimally invasive novel surgical approach. It can achieve complete full-thickness resection of lesions and individualized lymph node dissection for high-risk early gastric cancer with reliable perioperative safety, while preserving the anatomical structure and physiological function of the stomach.