腹腔镜辅助内镜全层切除术在早期胃癌外科治疗中的应用价值

左冰玉, 臧潞

中国实用外科杂志 ›› 2026, Vol. 46 ›› Issue (7) : 898-902.

PDF(1205 KB)
PDF(1205 KB)
中国实用外科杂志 ›› 2026, Vol. 46 ›› Issue (7) : 898-902. DOI: 10.19538/j.cjps.issn1005-2208.2026.07.08
专题笔谈·胃肿瘤的腹腔镜与内镜联合诊治

腹腔镜辅助内镜全层切除术在早期胃癌外科治疗中的应用价值

作者信息 +

The clinical value of laparoscopy-assisted endoscopic full-thickness resection in the surgical treatment of early gastric cancer

Author information +
文章历史 +

摘要

近年来随着精准外科理念的成功实践,腹腔镜与内镜联合手术在早期胃癌中的应用已证明安全有效,其中腹腔镜辅助内镜全层切除术联合吲哚菁绿荧光导航淋巴结清扫是一种可使病人获得与肿瘤根治术长期预后相近的保功能术式。其具有微创、R0切除保障(水平及垂直切缘阴性)、最大可能保留正常胃壁、全层缝合后一期愈合及胃功能恢复等优势。随着肿瘤外科治疗个体化、精准化趋势的发展,这一术式在早期胃癌外科治疗中的应用也必然得到更大发展。

Abstract

In recent years, with the successful implementation of the concept of precision surgery, the use of laparoscopy-endoscopy cooperative surgery in early gastric cancer has proven to be safe and effective. Among these techniques, laparoscopy-assisted endoscopic full-thickness resection combined with indocyanine green fluorescence-guided lymph node dissection is a function-preserving procedure that enables patients to achieve a long-term prognosis comparable to that of radical resection. It offers advantages such as minimally invasive surgery, guaranteed horizontal and vertical resection margins, maximal preservation of the normal gastric wall, and full-thickness suturing to ensure primary healing and the restoration of gastric function. With the growing trend towards personalised and precision surgical treatment of cancer, this procedure is bound to see further development.

关键词

内镜全层切除术 / 早期胃癌 / 吲哚菁绿 / 胃壁闭合

Key words

endoscopic full-thickness resection / early gastric cancer / indocyanine green / closure of the gastric wall

引用本文

导出引用
左冰玉, 臧潞. 腹腔镜辅助内镜全层切除术在早期胃癌外科治疗中的应用价值[J]. 中国实用外科杂志. 2026, 46(7): 898-902 https://doi.org/10.19538/j.cjps.issn1005-2208.2026.07.08
ZUO Bing-yu, ZANG Lu. The clinical value of laparoscopy-assisted endoscopic full-thickness resection in the surgical treatment of early gastric cancer[J]. Chinese Journal of Practical Surgery. 2026, 46(7): 898-902 https://doi.org/10.19538/j.cjps.issn1005-2208.2026.07.08
中图分类号: R6   

参考文献

[1]
Abe N, Mori T, Takeuchi H, et al. Successful treatment of early stage gastric cancer by laparoscopy-assisted endoscopic full-thickness resection with lymphadenectomy[J]. Gastrointest Endosc, 2008, 68(6):1220-1224. DOI: 10.1016/j.gie.2008.02.077.
[2]
An JY, Min JS, Hur H, et al. Laparoscopic sentinel node navigation surgery versus laparoscopic gastrectomy with lymph node dissection for early gastric cancer: Short-term outcomes of a multicentre randomized controlled trial (SENORITA)[J]. Br J Surg, 2020, 107(11): 1429-1439. DOI: 10.1002/bjs.11655.
[3]
臧潞, 左冰玉. 腹腔镜和内镜联合手术在早期胃癌治疗中应用价值[J]. 中国实用外科杂志, 2022, 42(10):1119-1122. DOI: 10.19538/j.cjps.issn1005-2208.2022.10.09.
[4]
Hiki N. History and further development of laparoscopic endoscopic cooperative surgery[J]. Dig Endosc, 2021, 34(suppl2): 64-67. DOI:10.1111/den.14157.
[5]
Hur H, Lim SG, Byun C, et al. Laparoscopy-assisted endoscopic full-thickness resection with basin lymphadenectomy based on sentinel lymph nodes for early gastric cancer[J]. J Am Coll Surg, 2014, 219(3): e29-e37. DOI: 10.1016/j.jamcollsurg.2014.05.016.
[6]
Cho WY, Kim YJ, Cho JY, et al. Hybrid natural orifice transluminal endoscopic surgery: Endoscopic full-thickness resection of early gastric cancer and laparoscopic regional lymph node dissection-14 human cases[J]. Endoscopy, 2010, 43(2): 134-139. DOI:10.1055/s-0030-1255955.
[7]
Nunobe S, Hiki N, Gotoda T, et al. Successful application of laparoscopic and endoscopic cooperative surgery (LECS) for a lateral-spreading mucosal gastric cancer[J]. Gastric Cancer, 2012, 15(3): 338-342. DOI:10.1007/s10120-012-0146-5.
[8]
Abe N, Takeuchi H, Yanagida O, et al. Endoscopic full-thickness resection with laparoscopic assistance as hybrid NOTES for gastric submucosal tumor[J]. Surg Endosc, 2009, 23(8): 1908-1913. DOI:10.1007/s00464-008-0317-y.
[9]
Abe N, Takeuchi H, Shibuya M, et al. Successful treatment of duodenal carcinoid tumor by laparoscopy‐assisted endoscopic full‐thickness resection with lymphadenectomy[J]. Asian J Endosc Surg, 2012, 5(2): 81-85. DOI:10.1111/j.1758-5910.2011.00120.x.
[10]
Cheng Y, Du M, Wang Y, et al. Risk factors of lymph node metastasis and prognosis in 891 Chinese patients with submucosal early gastric carcinoma,emphasizing differences between gastric cardiac and noncardiac origins[J]. Am J Surg Pathol, 2024, 48(10): 1293-1301. DOI:10.1097/PAS.0000000000002282.
[11]
周羽翙, 蔡振寨, 卢光荣, 等. 早期胃癌淋巴结转移规律及内镜切除的可行性[J]. 中国内镜杂志, 2015, 21(10): 1023-1027.
[12]
Kunisaki C, Akiyama H, Nomura M, et al. Lymph node status in patients with submucosal gastric cancer[J]. Ann Surg Oncol, 2006, 13(11): 1364-1371. DOI:10.1245/s10434-006-9061-5.
[13]
赵恩昊, 朱纯超, 曹晖, 等. 第7版日本《胃癌治疗指南》主要更新概览[J]. 中国实用外科杂志, 2025, 45(4): 386-391. DOI: 10.19538/j.cjps.issn1005-2208.2025.04.04.
[14]
Hiki N, Yamamoto Y, Fukunaga T, et al. Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection[J]. Surg Endosc, 2007, 22(7): 1729-1735. DOI:10.1007/s00464-007-9696-8.
[15]
Hiki N, Nunobe S. Laparoscopic endoscopic cooperative surgery (LECS) for the gastrointestinal tract: Updated indications[J]. Ann Gastroenterol Surg, 2019, 3(3): 239-246. DOI:10.1002/ags3.12238.
[16]
Shang L, Li Z, Zhou P, et al. 2024 Chinese expert consensus on clinical utilization of laparoscopic and endoscopic cooperative surgery for gastric tumors[J]. Chin Med J (Engl), 2025, 138(16): 1897-1903. DOI:10.1097/CM9.0000000000003639.
[17]
Lee AY, Kim YJ, Cho S, et al. Endoscopic resection and laparoscopic lymph node dissection for early gastric cancer beyond conventional endoscopic treatment indications: A 10-year outcome study[J]. Surg Endosc, 2024, 38(5): 2533-2541. DOI:10.1007/s00464-024-10761-7.
[18]
林渤参, 王鹿湄, 杨舒悦, 等. 腹腔镜辅助内镜全层切除术治疗早期胃癌的标准化流程(含视频)[J]. 中华消化内镜杂志, 2026, 43(3): 169-173. DOI:10.3760/cma.j.cn321463-20251023-00145.
[19]
Hiratsuka M, Miyashiro I, Ishikawa O, et al. Application of sentinel node biopsy to gastric cancer surgery[J]. Surgery, 2001, 129(3): 335-340. DOI: 10.1067/msy.2001.111699.
[20]
Nimura H, Narimiya N, Mitsumori N, et al. Infrared ray electronic endoscopy combined with indocyanine green injection for detection of sentinel nodes of patients with gastric cancer[J]. Br J Surg, 2004, 91(5): 575-579. DOI: 10.1002/bjs.4470.
[21]
Ichikura T, Morita D, Uchida T, et al. Sentinel node concept in gastric carcinoma[J]. World J Surg, 2002, 26(3):318-322. DOI:10.1007/s00268-001-0226-x.
[22]
Kinami S, Fujimura T, Ojima E, et al. PTD classification: proposal for a new classification of gastric cancer location based on physiological lymphatic flow[J]. Int J Clin Oncol, 2008, 13(4):320-329. DOI:10.1007/s10147-007-0755-x.
[23]
Tajima Y, Murakami M, Yamazaki K, et al. Sentinel node mapping guided by indocyanine green fluorescence imaging during laparoscopic surgery in gastric cancer[J]. Ann Surg Oncol, 2010, 17(7): 1787-1793. DOI:10.1245/s10434-010-0944-0
[24]
消化系统疾病国家临床医学研究中心, 消化健康全国重点实验室, 中华医学会消化内镜学分会. 早期胃癌双镜联合前哨淋巴结导航手术多学科临床诊疗实践专家共识(2026版)[J]. 中华消化内镜杂志, 2025, 42(12): 932-948. DOI: 10.3760/cma.j.cn321463-20251128-00507.
[25]
Chen QY, Xie JW, Zhong Q, et al. Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial[J]. JAMA Surg, 2020, 155(4): 300-311. DOI:10.1001/jamasurg.2019.6033.
[26]
Zhong Q, Wu D, Liu ZY, et al. Long-term oncological outcomes of indocyanine green fluorescence imaging-guided laparoscopic lymphadenectomy for gastric cancer: 5-year outcomes from the FUGES-012 randomized clinical trial[J]. BMC Med, 2025, 23(1): 497. DOI: 10.1186/s12916-025-04334-1.
[27]
Pang HY, Liang XW, Chen XL, et al. Assessment of indocyanine green fluorescence lymphography on lymphadenectomy during minimally invasive gastric cancer surgery: A systematic review and meta-analysis[J]. Surg Endosc, 2022, 36(3): 1726-1738. DOI: 10.1007/s00464-021-08830-2.
[28]
Miyashiro I, Hiratsuka M, Sasako M, et al. High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302[J]. Gastric Cancer, 2014, 17(2): 316-323. DOI: 10.1007/s10120-013-0285-3.
[29]
Cianchi F, Indennitate G, Paoli B, et al. The clinical value of fluorescent lymphography with indocyanine green during robotic surgery for gastric cancer: A matched cohort study[J]. J Gastrointest Surg, 2020, 24(10): 2197-2203. DOI: 10.1007/s11605-019-04382-y.
[30]
Ushimaru Y, Omori T, Fujiwara Y, et al. The feasibility and safety of preoperative fluorescence marking with indocyanine green (ICG) in laparoscopic gastrectomy for gastric cancer[J]. J Gastrointest Surg, 2019, 23(3): 468-476. DOI: 10.1007/s11605-018-3900-0.
[31]
Tanaka C, Kanda M, Funasaka K, et al. Detection of indocyanine green fluorescence to determine tumor location during laparoscopic gastrectomy for gastric cancer: Results of a prospective study[J]. Asian J Endosc Surg, 2020, 13(2): 160-167. DOI: 10.1111/ases.12710.
[32]
Cho M, Kim KY, Park SH, et al. Securing resection margin using indocyanine green diffusion range on gastric wall during nir fluorescence-guided surgery in early gastric cancer patients[J]. Cancers (Basel), 2022, 14(21): 5223. DOI: 10.3390/cancers14215223.
[33]
Hau SF, Chan SM. Endoscopic full-thickness resection of upper gastrointestinal tract: A review on closure techniques[J]. Clin Endosc, 2026, 59(2): 171-181. DOI: 10.5946/ce.2025.037.
[34]
Zhang M, Liu J, Gu JN, et al. Advances in endoscopic closure techniques for endoscopic full-thickness resection[J]. World J Gastrointest Endosc, 2025, 17(9): 107157. DOI: 10.4253/wjge.v17.i9.107157.
[35]
Niimi K, Ishibashi R, Mitsui T, et al. Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor[J]. Ann Transl Med, 2017, 5(8): 187. DOI: 10.21037/atm.2017.03.35.

脚注

利益冲突 所有作者均声明不存在利益冲突

基金

国家自然科学基金项目(82372933)
上海交通大学“交大之星”计划医工交叉研究基金重点项目(YG2023ZD03)

PDF(1205 KB)

Accesses

Citation

Detail

段落导航
相关文章

/