胃癌保功能手术中双镜联合技术应用价值及评价

臧明德, 司牟博, 刘凤林

中国实用外科杂志 ›› 2026, Vol. 46 ›› Issue (7) : 888-892.

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中国实用外科杂志 ›› 2026, Vol. 46 ›› Issue (7) : 888-892. DOI: 10.19538/j.cjps.issn1005-2208.2026.07.06
专题笔谈·胃肿瘤的腹腔镜与内镜联合诊治

胃癌保功能手术中双镜联合技术应用价值及评价

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Application value and evaluation of laparo-endoscopic combined surgery in function-preserving gastrectomy for gastric cancer

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摘要

在胃癌外科治疗由传统根治切除向根治性与功能保护并重转型的进程中,腹腔镜与内镜联合手术(LECS)凭借定位精准、创伤小、安全可控等优势,已成为早期胃癌保功能手术的核心支撑技术。内镜能够完成病灶精确定位、边界标记、黏膜层剥离与腔内显露,腹腔镜则可实现安全切除、淋巴结评估、胃壁缺损修复与腹腔内探查,二者协同作用可有效解决单一微创技术在病灶定位、切除安全、功能保留与根治保障之间的矛盾,显著减少围手术期并发症、加速术后康复、改善长期生活质量,在严格把握适应证、规范操作流程、强化多学科协作的前提下,可获得与标准胃癌根治术相当的肿瘤学疗效。随着技术不断优化、证据持续完善,双镜联合保功能手术将在早期胃癌治疗中发挥更重要的作用,为病人带来更小的创伤和更好的生活质量。

Abstract

In the transformation of gastric cancer surgery from traditional radical resection to emphasizing both radicality and function preservation, laparo-endoscopic combined surgery (LECS) has become a core supporting technique for function-preserving gastrectomy in early gastric cancer due to its advantages of precise localization, minimal invasiveness and controllable safety. Endoscopy enables precise lesion localization, boundary marking, mucosal dissection and intraluminal exposure, while laparoscopy achieves safe resection, lymph node evaluation, gastric wall defect repair and intra-abdominal exploration. The synergistic effect of the two modalities effectively resolves the contradictions among lesion localization, resection safety, function preservation and radical guarantee faced by single minimally invasive technique, significantly reduces perioperative complications, accelerates postoperative recovery, and improves long term quality of life. With strict adherence to appropriate indications, standardized procedural protocols, and enhanced multidisciplinary collaboration, it can achieve oncological outcomes comparable to those of standard radical gastrectomy. As the technique continues to be optimized and the clinical evidence matures, combined laparoscopic and endoscopic function-preserving surgery is expected to play an increasingly important role in the management of early gastric cancer, offering patients less surgical trauma and better quality of life.

关键词

胃癌 / 保功能手术 / 双镜联合 / 腹腔镜 / 内镜

Key words

gastric cancer / function-preserving surgery / laparoendoscopic combined surgery / laparoscopy / endoscopy

引用本文

导出引用
臧明德, 司牟博, 刘凤林. 胃癌保功能手术中双镜联合技术应用价值及评价[J]. 中国实用外科杂志. 2026, 46(7): 888-892 https://doi.org/10.19538/j.cjps.issn1005-2208.2026.07.06
ZANG Ming-de, SI Mou-bo, LIU Feng-lin. Application value and evaluation of laparo-endoscopic combined surgery in function-preserving gastrectomy for gastric cancer[J]. Chinese Journal of Practical Surgery. 2026, 46(7): 888-892 https://doi.org/10.19538/j.cjps.issn1005-2208.2026.07.06
中图分类号: R6   

参考文献

[1]
徐美东, 初元. 早期胃癌内镜诊治现状与挑战[J]. 中华消化杂志, 2025, 45(5): 309-313. DOI:10.3760/cma.j.cn311367-20250428-00175.
[2]
刘晓凌, 宋香谆, 闫岩. 术前超声内镜检查对胃癌病人T、N分期的诊断价值[J]. 癌症进展, 2023, 21(13):1471-1474. DOI:10.11877/j.issn.1672-1535.2023.21.13.21.
[3]
卢绮婷, 黄顺荣, 徐胜. 双镜联合手术治疗早期胃癌的研究进展[J]. 消化肿瘤杂志(电子版), 2025, 17(3): 371-377. DOI: 10.3969/j.issn.1674-7402.2025.03.016.
[4]
Hiki N, Yamamoto Y, Fukunaga T, et al. Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection[J]. Surg Endosc, 2008, 22(7): 1729-1735. DOI:10.1007/s00464-007-9696-8.
[5]
Holst MC, Kelly JB, Powley TL. Vagal preganglionic projections to the enteric nervous system characterized with phaseolus vulgaris-leucoagglutinin[J]. J Comp Neurol, 1997, 381(1): 81-100. DOI: 10.1002/(sici)1096-9861(19970428)381:1<81::aid-cne7>3.0.co;2-g.
[6]
Liu Y, Cui X, Zhang Y, et al. Efficacy of celiac branch preservation in Billroth-I reconstruction after laparoscopy-assisted distal gastrectomy[J]. J Surg Res, 2020, 245: 330-337. DOI:10.1016/j.jss.2019.07.074.
[7]
陈磊, 彭贵勇. 内外双镜联合治疗超内镜切除适应证的早期胃癌现状和前景[J]. 中华消化内镜杂志, 2025, 42(6): 438-442. DOI:10.3760/cma.j.cn321463-20241211-00510.
[8]
中国抗癌协会胃肠道间质瘤专业委员会, 中国抗癌协会胃癌专业委员会, 中华医学会消化内镜学分会经自然腔道内镜手术学组, 等. 中国胃肠道肿瘤双镜联合手术临床实践指南(2025,深圳)[J]. 消化肿瘤杂志(电子版) 2025, 17(3): 282-291. DOI:10.3760/cma.j.cn441530-20241125-00381.
[9]
中华医学会外科学分会胃肠外科学组. 吲哚菁绿近红外光成像在腹腔镜胃癌根治术中应用中国专家共识(2019版)[J]. 中国实用外科杂志, 2020, 40(2): 139-144. DOI:10.19538/j.cjps.issn1005-2208.2020.02.02.
[10]
中华医学会外科学分会胃肠外科学组. 吲哚菁绿近红外光成像技术在腹腔镜胃癌根治术中应用中国专家共识(2023版)[J]. 中国实用外科杂志, 2023, 43(2): 128-135. DOI:10.19538/j.cjps.issn1005-2208.2023.02.02.
[11]
Kitagawa Y, Takeuchi H, Takagi Y, et al. Sentinel node mapping for gastric cancer:a prospective multicenter trial in Japan[J]. J Clin Oncol, 2013, 31(29): 3704-3710. DOI:10.1200/JCO.2013.50.3789.
[12]
Hiki N. History and further development of laparoscopic endoscopic cooperative surgery[J]. Dig Endosc, 2022, 34(suppl 2): 64-67. DOI:10.1111/den.14157.
[13]
中华医学会外科学分会胃肠外科学组, 中国抗癌协会胃癌专业委员会, 中国医师协会外科医师分会上消化道外科专家工作组, 等. 早期胃癌内镜切除术后追加外科手术中国专家共识(2025版)[J]. 中国实用外科杂志, 2025, 45(10): 1087-1094. DOI:10.19538/j.cjps.issn1005-2208.2025.10.02.
[14]
王子萌, 菅悦洋, 郑智, 等. 非暴露式腹腔镜和内镜联合手术在早期胃癌治疗中应用进展[J]. 中国实用外科杂志, 2026, 46(1): 144-152. DOI:10.19538/j.cjps.issn1005-2208.2026.01.20.
[15]
De Brito SO, Libanio D, Pinto CMM, et al. Efficacy and safety of laparoscopic endoscopic cooperative surgery in upper gastrointestinal lesions: A systematic review and meta-analysis[J]. GE Port J Gastroenterol, 2023, 30(1): 4-19. DOI:10.1159/000526644.
[16]
Mitsui T, Niimi K, Yamashita H, et al. Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique[J]. Gastric Cancer, 2014, 17(3): 594-599. DOI:10.1007/s10120-013-0291-5.
[17]
Goto O, Takeuchi H, Kawakubo H, et al. Feasibility of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection as a new surgical method for early gastric cancer: A porcine survival study[J]. Gastric Cancer, 2015, 18(2): 440-445. DOI:10.1007/s10120-014-0358-y.
[18]
Nunobe S, HikiI N, Gotoda T, et al. Successful application of laparoscopic and endoscopic cooperative surgery (LECS) for a lateral-spreading mucosal gastric cancer[J]. Gastric Cancer, 2012, 15(3): 338-342. DOI:10.1007/s10120-012-0146-5.
[19]
Mitsui T, Goto O, Shimizu N, et al. Novel technique for f ull-thickness resection of gastric malignancy: feasibility of non-exposed endoscopic wall-inversion surgery (news) in porcine models[J]. Surg Laparosc Endosc Percutan Tech, 2013, 23(6): e217-e221. DOI:10.1097/SLE.0b013e31828e3f94.
[20]
Inoue H, Ikeda H, Hosoya T, et al. Endoscopic mucosal resec-tion,endoscopic submucosal dissection,and beyond: full-layer resection for gastric cancer with nonexposure technique (CLEAN-NET)[J]. Surg Oncol Clin N Am, 2012, 21(1): 129-140. DOI:10.1016/j.soc.2011.09.012.
[21]
Kikuchi S, Nishizaki M, Kuroda S, et al. Nonexposure laparoscopic and endoscopic cooperative surgery (closed laparoscopic and endoscopic cooperative surgery) for gastric submucosal tumor[J]. Gastric Cancer, 2017, 20(3): 553-557. DOI:10.1007/s10120-016-0641-1.
[22]
Ojima T, Nakamura M, Nakamori M, et al. Laparoscopic and endoscopic cooperative surgery is a feasible treatment procedure for intraluminal gastric gastrointestinal stromal tumors compared to endoscopic intragastric surgery[J]. Surg Endosc, 2018, 32(1): 351-357. DOI:10.1007/s00464-017-5683-x.
[23]
Iwakawa Y, Nishi M, Wada Y, et al. Feasibility of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor with tumor diameter of >5 cm[J]. J Med Invest, 2024, 71(1.2): 148-153. DOI:10.2152/jmi.71.148.
[24]
Zhao PY, Ma ZF, Jiao YN, et al. Laparoscopic and endoscopic cooperative surgery for early gastric cancer: Perspective for actual practice[J]. Front Oncol, 2022, 12: 969628. DOI:10.3389/fonc.2022.969628.
[25]
de Brito SO, Libânio D, Pinto CMM, et al. Efficacy and safety of laparoscopic endoscopic cooperative surgery in upper gastrointestinal lesions: A systematic review and Meta-analysis[J]. GE Port J Gastroenterol, 2022, 30(1): 4-19. DOI:10.1159/000526644.
[26]
Nomura E. Postoperative functional evaluation of gastrectomy for gastric cancer[J]. Chin J Cancer Res, 2022, 34(6): 567-574. DOI:10.21147/j.issn.1000-9604.2022.06.03.
[27]
Eom BW, Yoon HM, Kim YW, et al. Quality of life and nutritional outcomes of stomach-preserving surgery for early gastric cancer: A secondary analysis of the SENORITA randomized Trial[J]. Randomized Controlled Trial JAMA Surg, 2024, 159(8): 900-908. DOI:10.1001/jamasurg.2024.1210.
[28]
Hiki N, Nunobe S, Matsuda T, et al. Laparoscopic endoscopic cooperative surgery[J]. Dig Endosc, 2015, 27(2): 197-204. DOI:10.1111/den.12404.
[29]
Dai JH, Qian F, Chen L, et al. Novel combined endoscopic and laparoscopic surgery for advanced T2 gastric cancer: Two case reports[J]. World J Clin Cases, 2023, 11(9): 2029-2035. DOI:10.12998/wjcc.v11.i9.2029.
[30]
Maltzman H, Omae M, Klevebro F, et al. Laparoscopic and Endoscopic cooperative surgery as Rescue-treatment for Advanced gastric Cancer in patients Unfit for Surgery (LE-RACUS): protocol for a feasibility study[J]. Pilot Feasibility Stud, 2025, 11(1): 1. DOI:10.1186/s40814-024-01584-3.
[31]
Janjigian YY, Van Cutsem E, Muro K, et al. MATTERHORN: phase Ⅲ study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer[J]. Future Oncol, 2022, 18(20): 2465-2473. DOI:10.2217/fon-2022-0093.
[32]
Shitara K, Rha SY, Wyrwicz LS, et al. Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): An interim analysis of the multicentre,double-blind,randomised phase 3 study[J]. Lancet Oncol, 2024, 25(2): 212-224. DOI:10.1016/S1470-2045(23)00541-7.

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利益冲突 所有作者声明不存在利益冲突

基金

国家自然科学基金项目(82373381)

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