Abstract: Peri-implantitis is an advanced stage of peri-implant disease，which can lead to the destruction of peri-implant keratinized gingiva，the resorption of marginal bone tissue，implant loosening and even loss. At present，the specific biological mechanism of the interaction between peri-implantitis and systemic risk factors is unclear，but existing research evidence suggests that there may be a reinforcing relationship between them. This article will explore the systemic risk factors related to peri-implantitis from the perspectives of aging，smoking，and systemic diseases，etc.，in order to provide a reference for the prevention and treatment of related diseases after implant implantation，and to play an important role in the management of patients receiving dental implant restoration.

Key words: dental implants, peri-implantitis, systemic diseases, risk factors

摘要： 种植体周炎是种植体周围疾病的晚期阶段，逐渐发展可引起种植体周围角化龈破坏、边缘骨组织吸收、种植体松动甚至脱落。目前，种植体周炎与全身危险因素之间相互作用的具体生物学机制尚不清楚，现有证据表明二者可能存在促进关系。文章将从衰老、吸烟、全身性疾病等角度探讨与种植体周炎相关的全身危险因素，以期为种植体植入后相关疾病的防治提供参考，并在种植义齿修复患者的管理中发挥重要作用。

关键词: 种植义齿, 种植体周炎, 全身疾病, 危险因素